Mutations in the glucokinase gene of the fetus result in reduced placental weight

Diabetes Care
B ShieldsA T Hattersley

Abstract

In human pregnancy, placental weight is strongly associated with birth weight. It is uncertain whether there is regulation of the placenta by the fetus or vice versa. We aimed to test the hypothesis that placental growth is mediated, either directly or indirectly, by fetal insulin. Birth weight and placental weight were measured in 43 offspring of 21 parents with mutations in the glucokinase (GCK) gene (25 had inherited the mutation and 18 had not), which results in reduced fetal insulin secretion. Birth weight, placental weight, umbilical cord insulin, and maternal glucose and insulin concentrations were measured in 573 nondiabetic, healthy, term pregnancies. GCK mutation carriers were lighter and also had smaller placentas (610 vs. 720 g, P = 0.042). This difference was also seen in 17 discordant sibling pairs (600 vs. 720 g, P = 0.003). GCK mRNA was not detected in the placenta by RT-PCR. In the normal pregnancies, placental weight was strongly correlated with birth weight (r = 0.61, P < 0.001). Cord insulin concentrations were directly related to placental weight (r = 0.28) and birth weight (r = 0.36) (P < 0.001 for both). These results suggest that insulin, directly or indirectly, plays a role in placental growth, especial...Continue Reading

References

Aug 1, 1967·The Journal of Pediatrics·M Winick, A Noble
Jan 1, 1994·Molecular Aspects of Medicine·G Desoye, E Shafrir
Mar 1, 1994·The Journal of Clinical Investigation·M M ByrneG I Bell
Jan 1, 1995·Reproduction, Fertility, and Development·W W Hay
Jul 1, 1997·Microscopy Research and Technique·G DesoyeP Kaufmann
Jul 14, 1998·Nature Genetics·A T HattersleyS Ellard
Aug 12, 1998·Placenta·P BoileauS Hauguel-de Mouzon
Feb 7, 2001·Pediatric Research·T Jansson
Feb 10, 2006·Paediatric and Perinatal Epidemiology·Bridget KnightAndrew T Hattersley

❮ Previous
Next ❯

Citations

Feb 26, 2008·Diabetologia·S EllardUNKNOWN European Molecular Genetics Quality Network (EMQN) MODY group
Dec 4, 2012·Nature Genetics·Momoko HorikoshiUNKNOWN Early Growth Genetics (EGG) Consortium
Apr 8, 2010·Nature Genetics·Rachel M FreathyMark I McCarthy
Apr 27, 2005·Archives of Disease in Childhood·S JarvisUNKNOWN SCPE collaboration of European Cerebral Palsy Registers
Oct 24, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Carl E Hunt
Aug 17, 2002·BMJ : British Medical Journal·Debbie A LawlorShah Ebrahim
Dec 29, 2000·Journal of Clinical Pathology·C D Byrne, D I Phillips
May 15, 2004·Journal of Epidemiology and Community Health·P McCarronA T Hattersley
Nov 15, 2001·Journal of Epidemiology and Community Health·P MagnusR Skjaerven
Jun 27, 2007·BMC Medical Genetics·Stéphane CauchiClaire Levy-Marchal
Apr 5, 2011·Genome Medicine·Richard M Watanabe
Aug 24, 2012·Disease Models & Mechanisms·Jonathan C K Wells
Feb 21, 2009·Diabetes·Rachel M FreathyAndrew T Hattersley
Jul 22, 2014·Current Genetic Medicine Reports·Stephanie A SteinToni I Pollin
Sep 14, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Cristina Colom, Rosa Corcoy
May 27, 2009·Journal of Anatomy·Ursula HidenGernot Desoye
Apr 25, 2015·Annals of the New York Academy of Sciences·Jeffrey W Kleinberger, Toni I Pollin
May 4, 2015·American Journal of Obstetrics and Gynecology·Siobhan BaconMaria M Byrne
Sep 17, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Gernot Desoye, Mireille van Poppel
Dec 3, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Siri Atma W GreeleyLouis H Philipson
Aug 25, 2005·Trends in Endocrinology and Metabolism : TEM·Rebecca Simmons
Nov 25, 2004·Pediatric Clinics of North America·Meryl S Cohen
Nov 29, 2005·Endocrinology and Metabolism Clinics of North America·Rebecca Simmons
Jan 9, 2013·Arquivos brasileiros de endocrinologia e metabologia·Thais DellaMannaAndré Fernandes Reis
Jul 1, 2012·Hormones : International Journal of Endocrinology and Metabolism·Cristina ColomRosa Corcoy
Oct 1, 2019·Canadian Journal of Diabetes·Sarah MonsonegoJanine Malcolm
Jan 19, 2021·Zeitschrift für Geburtshilfe und Neonatologie·Hans Gottfried Simon

❮ Previous
Next ❯