Mutations in the hepatitis B virus precore/core gene and core promoter in patients with severe recurrent disease following liver transplantation

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
J S McMillanS A Locarnini

Abstract

Recurrent hepatitis B virus (HBV) infection is a major problem in patients undergoing liver transplantation. Previously, we reported that infection with HBV strains containing a mutation in the precore region (G-to-A at nucleotide 1896) was associated with severe recurrent disease posttransplantation. In this study we investigated other mutations in the precore/core gene and core promoter which may be associated with this severe recurrence. The precore/core gene and core promoter of HBV from pre and posttransplantation sera of 15 patients with HBV recurrence were amplified by polymerase chain reaction (PCR) and sequenced. Pre and posttransplant sequences were very similar for each patient. HBV from patients who developed severe recurrence had significantly more mutations in both the nucleotide (P < .05) and predicted amino acid (P < .05) sequences of the precore/core gene, but not in the core promoter, than virus from patients with mild recurrence. There was also an apparent link between severe disease and HBV strains of genotype D (P < .05). The number of nucleotide and amino acid mutations in the precore/core gene was strongly associated with the presence of the precore mutation (P < .01). Mutations were found throughout the ...Continue Reading

Citations

Jan 1, 1997·International Journal of Clinical & Laboratory Research·H E Blum
May 11, 2002·Journal of Cellular and Molecular Medicine·C Kreutz
Dec 8, 2004·Journal of Clinical Microbiology·Karin Kidd-LjunggrenJonas Bläckberg
Feb 28, 2006·Journal of Virology·Philip MeulemanGeert Leroux-Roels
Nov 5, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·G W McCaughanP W Angus
Oct 13, 2007·Digestive Diseases and Sciences·Carlos KupskiVirgínia M Schmitt
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M FriedtS Wirth
Oct 29, 2011·Clinics in Liver Disease·Corinne Buchanan, Tram T Tran
Oct 14, 2009·Journal of Gastroenterology and Hepatology·Geoff McCaughan
May 25, 2002·The Journal of General Virology·Karin Kidd-LjunggrenAlistair H Kidd
Mar 18, 2008·The Journal of General Virology·Saffie JammehPeter Karayiannis
Apr 25, 2007·Virology·Chiara De MaddalenaGianguglielmo Zehender
Feb 3, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Raffaele GirlandaSuzanne Norris
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C M HuntL D Condreay
May 31, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Harshad C DevarbhaviMichael B Ishitani
Dec 22, 1999·Journal of Viral Hepatitis·A Kramvis, M C Kew
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Zoulim, C Trépo
Dec 2, 2000·Journal of Gastroenterology and Hepatology·R Williams, S M Riordan
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Man-Fung Yuen, Ching-Lung Lai
Oct 25, 2011·Hepatology International·Geoffrey W McCaughan
Oct 24, 2014·World Journal of Gastroenterology : WJG·Tahereh GhazianiHerbert L Bonkovsky
Oct 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Paul GaglioUNKNOWN National Institutes of Health Hepatitis B Virus-Orthotopic Liver Transplantation Study Group
Mar 1, 2013·Emerging Microbes & Infections·Shuping TongYu-Mei Wen

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