PMID: 8995670Feb 1, 1997Paper

Mutations in the matrix protein of human immunodeficiency virus type 1 inhibit surface expression and virion incorporation of viral envelope glycoproteins in CD4+ T lymphocytes

Journal of Virology
Y M LeeX F Yu

Abstract

Highly conserved amino acids in the second helix structure of the human immunodeficiency virus type 1 (HIV-1) MA protein were identified to be critical for the incorporation of viral Env proteins into HIV-1 virions from transfected COS-7 cells. The effects of these MA mutations on viral replication in the HIV-1 natural target cells, CD4+ T lymphocytes, were evaluated by using a newly developed system. In CD4+ T lymphocytes, mutations in the MA domain of HIV-1 Gag also inhibited the incorporation of viral Env proteins into mature HIV-1 virions. Furthermore, mutations in the MA domain of HIV-1 Gag reduced surface expression of viral Env proteins in CD4+ T lymphocytes. The synthesis of gp160 and cleavage of gp160 to gp120 were not significantly affected by MA mutations. On the other hand, the stability of gp120 in MA mutant-infected cells was significantly reduced compared to that in the parental wild-type virus-infected cells. These results suggest that functional interaction between HIV-1 Gag and Env proteins is not only critical for efficient incorporation of Env proteins into mature virions but also important for proper intracellular transport and stable surface expression of viral Env proteins in infected CD4+ T lymphocytes. ...Continue Reading

References

Aug 1, 1992·Journal of Virology·M SuomalainenH Garoff
Jun 1, 1991·AIDS·J W Wills, R C Craven
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·V Bruss, D Ganem
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R J OwensR W Compans
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·V KaracostasB Moss
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R L WilleyR D Klausner
Jan 1, 1988·Annual Review of Microbiology·E B Stephens, R W Compans
Mar 1, 1994·Journal of Virology·S LopezJ H Strauss
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·C P HillW I Sundquist

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Citations

Jan 31, 2002·AIDS·H G Göttlinger
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·T Murakami, E O Freed
Nov 13, 2001·The Journal of Biological Chemistry·Maria José CortésJuan Lama
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K V KhannaR B Markham
Dec 12, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T L CaddP Liljeström
Mar 4, 2011·Journal of Virology·Colleen M NovielloEric Barklis
Dec 10, 1999·Journal of Virology·L J ParentR C Craven
Jul 1, 2016·Microbiology and Molecular Biology Reviews : MMBR·Guangdi Li, Erik De Clercq
Feb 20, 2018·Virology Journal·Cyprien BeraudDanielle Perez Bercoff
Nov 14, 1998·Virology·L Dawson, X F Yu
May 28, 2013·Retrovirology·Eveline Santos da SilvaDanielle Perez Bercoff

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