Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster

Molecular and Cellular Biology
Y NakanoDaisuke Yamamoto

Abstract

Mutations in the spin gene are characterized by an extraordinarily strong rejection behavior of female flies in response to male courtship. They are also accompanied by decreases in the viability, adult life span, and oviposition rate of the flies. In spin mutants, some oocytes and adult neural cells undergo degeneration, which is preceded by reductions in programmed cell death of nurse cells in ovaries and of neurons in the pupal nervous system, respectively. The central nervous system (CNS) of spin mutant flies accumulates autofluorescent lipopigments with characteristics similar to those of lipofuscin. The spin locus generates at least five different transcripts, with only two of these being able to rescue the spin behavioral phenotype; each encodes a protein with multiple membrane-spanning domains that are expressed in both the surface glial cells in the CNS and the follicle cells in the ovaries. Orthologs of the spin gene have also been identified in a number of species from nematodes to humans. Analysis of the spin mutant will give us new insights into neurodegenerative diseases and aging.

References

Jul 1, 1979·Behavior Genetics·J M Jallon, Y Hotta
Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Apr 1, 1976·Biochemical Medicine·K Yagi
Nov 1, 1992·Journal of Neurobiology·J W TrumanS Robinow
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jan 1, 1989·Advances in Experimental Medicine and Biology·D Harman
Jul 1, 1987·Chemistry and Physics of Lipids·M TsuchidaK Aibara
Mar 1, 1973·Analytical Biochemistry·B L FletcherA L Tappel
Oct 22, 1982·Science·G M Rubin, A C Spradling
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Apr 29, 1994·Science·K WhiteH Steller
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·H ItoD Yamamoto
Jan 1, 1997·Annual Review of Entomology·D YamamotoA Komatsu
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·K D FinleyM McKeown
Sep 12, 1997·Science·F W Pfrieger, B A Barres
Feb 21, 1998·The EMBO Journal·E K EvansS Kornbluth
Nov 13, 1998·Current Biology : CB·M Mutsuddi, J R Nambu
Dec 19, 1998·The EMBO Journal·C ClaveríaM Torres
Feb 13, 1999·Cell·D L Vaux, S J Korsmeyer
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·W N HainingH Steller
May 24, 2000·Progress in Neurobiology·M Tissot, R F Stocker

❮ Previous
Next ❯

Citations

Jan 30, 2002·Archives of Insect Biochemistry and Physiology·Kazue Usui-AokiDaisuke Yamamoto
Nov 1, 2011·Invertebrate Neuroscience : in·Samantha HindleSean T Sweeney
Jun 18, 2009·Apoptosis : an International Journal on Programmed Cell Death·Tracy L PritchettKimberly McCall
Jun 27, 2009·Cell Death and Differentiation·B P BassK McCall
Jun 19, 2010·Nature Chemical Biology·Henrik Fyrst, Julie D Saba
May 9, 2013·Nature Communications·Akira SakuraiDaisuke Yamamoto
Jun 2, 2005·Nature Reviews. Molecular Cell Biology·Eric H Baehrecke
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yueguang RongMichael J Lenardo
Oct 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Valerie J MiltonSean T Sweeney
May 17, 2012·Development, Growth & Differentiation·Yu ToganeHidenobu Tsujimura
Oct 4, 2005·The Journal of Clinical Investigation·Beth Levine, Junying Yuan
Jun 17, 2010·Journal of Cell Science·Mohiddin LoneAndreas Prokop
Jan 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Angeline Lim, Rachel Kraut
Aug 28, 2013·Glycoconjugate Journal·Ivana NemčovičováIain B H Wilson
Aug 8, 2013·Biochimica Et Biophysica Acta·Tsuyoshi NishiAkihito Yamaguchi
Sep 25, 2012·Experimental Cell Research·Yang Chen, Li Yu
Jun 28, 2012·Biochimica Et Biophysica Acta·Ana OliveraRichard L Proia
May 4, 2011·Developmental Neurobiology·Yeliz Yuva-Aydemir, Christian Klämbt
Oct 5, 2010·Evolution & Development·Teiya KijimotoArmin P Moczek
Jan 11, 2011·Journal of Neurochemistry·Rachel Kraut
Jul 31, 2013·Evolution; International Journal of Organic Evolution·Y ChuR Sousa-Neves
Jan 22, 2010·Archives of Insect Biochemistry and Physiology·Akira SakuraiDaisuke Yamamoto
Mar 31, 2005·Seminars in Cell & Developmental Biology·J S BaumK McCall
Oct 23, 2014·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·L ZwartsP Callaerts
May 11, 2013·Biochimica Et Biophysica Acta·Tomoyuki Sasaki, Shuji Kishi
Jun 11, 2014·Journal of Neurogenetics·Shingo KimuraDaisuke Yamamoto
Jun 30, 2005·BMC Neuroscience·Faith L W Liebl, David E Featherstone
Jan 23, 2013·Biochimica Et Biophysica Acta·Michael BondClaire Russell
Sep 10, 2004·Developmental Biology·Kimberly McCall

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis