Mutations in the tyrosine kinase domain of the EGFR gene are rare in synovial sarcoma

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Beata BodeHolger Moch

Abstract

The prognosis of patients with synovial sarcomas is poor. New therapeutic strategies, such as target inhibition of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) with erlotinib and gefinitib, could be effective, because most synovial sarcomas overexpress this protein. In lung cancer, the responsiveness to gefinitib is strongly related to the presence of mutations in the tyrosine kinase domain of the EGFR gene, while erlotinib sensitivity seems to be partly linked to chromosome 7 polysomy or gene amplification. To clarify the role of EGFR in synovial sarcoma and to explore the potential for a targeted therapy approach, we have examined 13 of these soft tissue tumors. We have analyzed the EGFR expression by immunohistochemistry, searched for polysomy and gene amplification with fluorescence in situ hybridization (FISH) and screened for EGFR mutations in exons 18-21 using PCR and direct sequencing. All 13 tumors showed strong diffuse or focal EGFR expression. No amplifications of the EGFR gene were found. In contrast, several point mutations were identified in exons 18-21 of two synovial sarcomas. Whereas one of these tumors carried only a synonymous mutation, two missense mutations in exons 19 and 21 ...Continue Reading

References

Dec 15, 1985·International Journal of Cancer. Journal International Du Cancer·B GustersonB Reeves
May 15, 1994·International Journal of Cancer. Journal International Du Cancer·G SauterF Waldman
Dec 6, 2001·The Journal of Biological Chemistry·Hiroyuki KatoRobert G Roeder
Apr 20, 2002·Lancet·Torsten O NielsenMatt van de Rijn
Nov 30, 2002·Journal of Cancer Research and Clinical Oncology·Violetta BarbashinaMeera Hameed
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
Oct 7, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tatsuo ItoKenji Shimizu
Mar 3, 2005·Journal of the National Cancer Institute·Hisayuki ShigematsuAdi F Gazdar
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hisashi NagaharaMasaki Mori
Mar 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William Pao, Vincent A Miller
May 5, 2005·Journal of the National Cancer Institute·Federico CappuzzoMarileila Varella-Garcia
Jul 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Toshimi TakanoTomohide Tamura
Jul 15, 2005·The New England Journal of Medicine·Ming-Sound TsaoFrances A Shepherd
Jul 15, 2005·The New England Journal of Medicine·Daniela S Krause, Richard A Van Etten
Aug 19, 2005·The New England Journal of Medicine·Matthew A ClarkJ Meirion Thomas
Sep 1, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Harri SihtoHeikki Joensuu
Oct 19, 2005·Cancer Research·Kristin BairdPaul S Meltzer

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Citations

Feb 2, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michael J CascioAndrew E Horvai
Mar 16, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marc HinterbergerHolger Moch
Jul 24, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lisandro F Lopes, Carlos E Bacchi
Jun 5, 2007·Current Opinion in Oncology·Bernd KasperAhmad Awada
Jan 13, 2012·American Journal of Clinical Oncology·Huan T HaRashmi Chugh
Jun 6, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Xiaofei Qiu, Elizabeth Montgomery
Oct 10, 2006·Future Oncology·Abha A Gupta, Alberto S Pappo
Sep 26, 2012·Virchows Archiv : an International Journal of Pathology·Adriana von TeichmanPeter Schraml
Jun 18, 2009·Journal of Cancer Research and Clinical Oncology·Beata ZahorowskaJia-Lin Yang
Oct 21, 2011·Expert Opinion on Investigational Drugs·Bruno VincenziGiuseppe Tonini
Oct 28, 2014·Cancer Investigation·Hongsheng WangZhengdong Cai
May 19, 2007·Human Pathology·Heide Schreiber-FacklamRenata Flury
Sep 9, 2015·Frontiers in Oncology·Jonathan NoujaimCharles Keller
May 31, 2017·International Journal of Molecular Sciences·Jia-Lin YangPhilip J Crowe
Jul 25, 2007·Genes, Chromosomes & Cancer·B Bode-LesniewskaD R Zimmermann
Nov 17, 2012·The American Journal of Surgical Pathology·Marie-Angela WulfVerena Tischler
Sep 29, 2015·Oncotarget·Myrella VlenterieYvonne M H Versleijen-Jonkers
Oct 8, 2020·Current Oncology Reports·Marc El BeainoPatrick P Lin
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wanqing LiuMark J Ratain
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wenhong RenDina Lev
Dec 11, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David O AzorsaJaved Khan
Aug 1, 2021·Virchows Archiv : an International Journal of Pathology·Mauro VasellaBeata Bode-Lesniewska
Jul 10, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pedro H Imenez SilvaNilufar Mohebbi

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