Mutations in TP53 are exclusively associated with del(17p) in multiple myeloma.

Haematologica
Laurence LodéH Avet-Loiseau

Abstract

Deletion of the 17p13 chromosomal region [del(17p)] is associated with a poor outcome in multiple myeloma. Most of the studies have targeted the TP53 gene for deletion analyses, although no study showed that this gene is the deletion target. In order to address this issue, we sequenced the TP53 gene in 92 patients with multiple myeloma at diagnosis, 54 with a del(17p) and 38 lacking del(17p). At least one mutation was found in 20 patients, all of them presenting a del(17p). The analysis of the mutation location showed that virtually all of them occurred in highly conserved domains involved in the DNA-protein interactions. In conclusion, we showed that 37% of the myeloma patients with del(17p) present a TP53 mutation versus 0% in patients lacking the del(17p). The prognostic significance of these mutations remains to be evaluated.

References

Jan 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thierry SoussiChristophe Béroud
Jan 12, 2007·Leukemia·W J ChngR Fonseca
May 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Irina GryshchenkoInge Tinhofer

❮ Previous
Next ❯

Citations

Mar 5, 2013·International Journal of Hematology·Marta Chesi, P Leif Bergsagel
Apr 13, 2012·Nature Reviews. Cancer·Gareth J MorganFaith E Davies
Mar 18, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nikhil C Munshi, Hervé Avet-Loiseau
Oct 2, 2012·The Journal of Clinical Investigation·W Michael Kuehl, P Leif Bergsagel
Dec 14, 2011·Hematology·Marta Chesi, P Leif Bergsagel
Oct 16, 2012·Haematologica·Florence Nguyen-KhacUNKNOWN Groupe d’Etude des Lymphomes de l’Adulte (GELA)
May 8, 2014·Advances in Hematology·Steven M PrideauxTimothy J Chevassut
Jul 6, 2014·BioMed Research International·Chonglei Bi, Wee Joo Chng
Jul 17, 2014·BioMed Research International·P J Teoh, W J Chng
Aug 8, 2014·BioMed Research International·Sanjay de MelWee-Joo Chng
Dec 12, 2012·Expert Review of Hematology·Kevin D BoydFaith E Davies
Jun 7, 2013·Expert Opinion on Biological Therapy·Gabriella MissoMichele Caraglia
May 20, 2015·Current Opinion in Genetics & Development·Raphaël Szalat, Nikhil C Munshi
Dec 18, 2014·Cancer Biology & Therapy·Patricia Gomez-BougieMartine Amiot
Oct 1, 2011·Genes, Chromosomes & Cancer·Kevin D BoydUNKNOWN NCRI Haematology Oncology Studies Group
Mar 4, 2014·British Journal of Haematology·Annamaria BrioliGareth J Morgan
Oct 9, 2015·Journal of Hematology & Oncology·Jacqueline E NollAndrew Cw Zannettino
Jul 16, 2011·Journal of Biomedicine & Biotechnology·Mariana VarnaAnne Janin
Oct 11, 2014·British Journal of Haematology·Klaus M KortümEsteban Braggio
Feb 22, 2012·Upsala Journal of Medical Sciences·Helena Jernberg-Wiklund, Kenneth Nilsson
Dec 10, 2014·Clinical Lymphoma, Myeloma & Leukemia·Annamaria BrioliGareth J Morgan
Oct 19, 2010·Cancer Cell·Marta Chesi, P Leif Bergsagel
Jul 10, 2014·Blood·Benoît TessoulinCatherine Pellat-Deceunynck
Jan 30, 2015·Blood·Jill CorreHervé Avet-Loiseau
Nov 28, 2012·Clinical Journal of Oncology Nursing·Stephanie JacobsonThomas Rosenzweig
Nov 3, 2016·Nature Reviews. Clinical Oncology·Salomon ManierIrene M Ghobrial
Dec 6, 2016·International Journal of Molecular Sciences·Ana B HerreroNorma C Gutiérrez
Nov 26, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Inhye E AhnOla Landgren
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Avet-Loiseau HervéMinvielle Stéphane
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Constantine S MitsiadesPaul G Richardson
Aug 19, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian A WalkerGareth J Morgan
Jan 4, 2018·International Journal of Molecular Sciences·Pierre-Samuel GillardinAgnès Moreau-Aubry
Aug 21, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·David MondererFrédéric Blanchard
Jan 30, 2019·The Cancer Journal·Jill Corre, Hervé Avet-Loiseau
Feb 7, 2020·International Journal of Hematology·Yusuke Furukawa, Jiro Kikuchi
Feb 14, 2020·Cancers·Vanessa PintoM Helena Vasconcelos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.