Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C

Hepatitis Monthly
Yong HuangAilong Huang

Abstract

Mutations in basal core promoter (BCP) and precore regions of hepatitis B virus (HBV) are associated with course and treatment outcomes of chronic HBV infection. While BCP and precore mutation analysis have been carried out in adult patients between different genotypes, this analysis has rarely been performed for chronically infected children. The aim of this study was to assess the mutation profiles of BCP and precore regions in different HBV genotypes in chronically infected children. A cohort of 245 children and 92 adults with chronic HBV infection was included in this study. BCP and precore regions were analyzed by PCR amplification and sequenced. Ten nucleotide positions, including nt1679, nt1721, nt1753, nt1757, nt1758, nt1762, nt1764, nt1775, nt1856 and nt1858 in BCP/precore regions of HBV genome, showed obviously higher frequencies of mutation in genotype C subjects than in genotype B subjects among children, while there were only three positions, including nt1679, nt1758 and nt1775 showing higher mutation frequencies in genotype C subjects than in genotype B subjects in adults. Several combined mutations were obviously highly distributed in children with chronic HBV genotype C infection, such as G1721A/A1775G/T1858C tr...Continue Reading

References

Dec 22, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E OritoS Iino
Dec 29, 2000·Journal of Hepatology·J H KaoD S Chen
Jul 19, 2002·The New England Journal of Medicine·Hwai-I YangUNKNOWN Taiwan Community-Based Cancer Screening Project Group
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Chien-Jen ChenUNKNOWN REVEAL-HBV Study Group
Jan 9, 2007·World Journal of Gastroenterology : WJG·Stephan Schaefer
Jan 9, 2007·World Journal of Gastroenterology : WJG·Thomas F BaumertFritz von Weizsäcker
Mar 27, 2007·Virus Research·Alan Kay, Fabien Zoulim
Jan 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henry Lik-Yuen ChanTony Shu-Kam Mok
Nov 20, 2013·Journal of Medical Virology·Maria NordinKarin Kidd-Ljunggren
Jul 1, 2014·World Journal of Gastroenterology : WJG·Alexandra Alexopoulou, Peter Karayiannis

❮ Previous
Next ❯

Citations

Apr 25, 2021·Journal of Viral Hepatitis·Stewart L CooperUNKNOWN Hepatitis B Research Network (HBRN)
Aug 7, 2021·Journal of Viral Hepatitis·William M LeeUNKNOWN Hepatitis B Research Network (HBRN)

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.