PMID: 9180136May 29, 1997Paper

Mutations of O6-methylguanine-DNA methyltransferase gene in esophageal cancer tissues from Northern China

International Journal of Cancer. Journal International Du Cancer
L WangM Wu

Abstract

Epidemiologic studies have implicated the involvement of environmental factors in the etiology of esophageal cancer (EC). Our previous data have indicated that EC patients and their blood relatives show genomic instability and are deficient in repair of DNA damage induced by N-nitroso-compounds and related genotoxic agents. Thus, exposure to high levels of N-alkylnitrosamines, which are known animal carcinogens and which induce alkyl adducts in DNA, may be causally linked to EC. Among the alkyl adducts, O6-alkylguanine was shown to be the critical one related to carcinogenic lesions; its repair varies widely in a tissue-specific fashion. O6-methylguanine-DNA methyltransferase (MGMT) is responsible for its repair. Hence, inactivating mutations in this protein would impair the efficiency of the repair process. To screen for possible mutations in the MGMT polypeptide in EC patients, we analyzed a highly conserved region of the MGMT gene in 40 EC tissues and lymphocytes of 6 high-risk EC family members from high EC areas of Northern China by polymerase chain reaction single-strand conformation polymorphism and by direct sequencing of PCR products. Ten base substitutions (point mutations) within 8 codons of 7 EC samples were identif...Continue Reading

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Citations

Feb 4, 2010·World Journal of Gastroenterology : WJG·Wen-Jing MaXiao-Mei Lu
Jul 13, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jia-Jun ZhaoDa-Wei Sun
May 14, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mihi YangFred F Kadlubar
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Asad Ur RehmanSyed Akhtar Husain
Feb 26, 1999·Environmental and Molecular Mutagenesis·Z YuB W Glickman
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Arno PützHartmut M Rabes
Jul 19, 2002·International Journal of Cancer. Journal International Du Cancer·Deyin XingDongxin Lin
Apr 5, 2008·International Journal of Cancer. Journal International Du Cancer·James DoeckeUNKNOWN Australian Cancer Study
Aug 12, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Hidenobu SoejimaTsunehiro Mukai
Apr 2, 2004·Nature Reviews. Cancer·Stanton L Gerson
Jan 27, 2012·Pathology Oncology Research : POR·Gabriella LivideFrancesca Ariani
Jul 11, 2014·Cellular Oncology (Dordrecht)·Adfar YousufSyed Mudassar
Sep 26, 2020·Biomarker Research·Aiai Gao, Mingzhou Guo
May 8, 2014·Genes, Chromosomes & Cancer·Frida AppelqvistCharlotta Enerbäck

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