PMID: 11927008Apr 3, 2002Paper

Mutations of p53, c-kit, K-ras, and beta-catenin gene in non-Hodgkin's lymphoma of adrenal gland

Japanese Journal of Cancer Research : Gann
Shin-ichi NakatsukaK Aozasa

Abstract

Malignant lymphoma of the adrenal gland is a rare disease, usually with diffuse large cell morphology and B-cell immunophenotype, and often associated with Epstein-Barr virus infection. In this study, mutations of p53, c-kit, K-ras, and beta-catenin gene were analyzed in 17 cases (13 males and four females with ages ranging from 25 to 84 years) of such lymphomas by polymerase chain reaction-single strand conformation polymorphism followed by direct sequencing. Selected exons in each gene, representing hot spots, were analyzed. All 44 mutations detected were single-nucleotide substitutions and 33 were missense mutations. Nineteen mutations were detected in exon 5 and / or 7 of the p53 gene in nine of 17 cases (52.9%) and 21 in exon 11 and / or 17 of the c-kit gene in 10 of 14 cases (71.4%). Bilateral adrenal lesions in one case who had not received any adjuvant therapy showed different mutational patterns of the p53 and c-kit genes, suggesting different clonal evolution of lymphoma between the left and right sides. Mutation at codon 13 of the K-ras gene was detected in one of 14 cases (7.1%), and in exon 3 of the beta-catenin gene in three of 12 cases (25%). All but one mutation were transition mutations, indicating that some en...Continue Reading

References

Jul 5, 1991·Science·M HollsteinC C Harris
Jun 6, 1991·Nature·A J LevineC A Finlay
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G GaidanoR Dalla-Favera
Jun 1, 1990·European Journal of Clinical Investigation·M Barbacid
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A NeriR Dalla-Favera
Jul 1, 1995·British Journal of Cancer·D J AdamsonN E Haites
Dec 1, 1995·Molecular and Cellular Biology·J L AbrahamsonA Bernstein
Aug 21, 1997·The New England Journal of Medicine·A IchikawaT Hotta
Feb 26, 1998·Leukemia & Lymphoma·F Z Al-FiarF Shepherd
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·A de La CosteC Perret
Sep 4, 1998·Science·T C HeK W Kinzler
Apr 13, 2000·Japanese Journal of Cancer Research : Gann·T TakakuwaK Aozasa
Apr 26, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·T LiK Aozasa
Jan 3, 2001·The New England Journal of Medicine·H DöhnerP Lichter
Feb 1, 1961·Medicine·S A ROSENBERGL F CRAVER

❮ Previous
Next ❯

Citations

Jun 19, 2013·Annals of Hematology·Armin Rashidi, Stephen I Fisher
Sep 3, 2013·The Journal of Heredity·Andrea D ShortBill Ollier
Oct 27, 2006·Oral Oncology·Dalal Abdullah Al-HakeemStephen Porter
Mar 22, 2007·American Journal of Hematology·Takeaki TomoyoseNobuyuki Takasu
Nov 8, 2005·Pathology International·Efsevia VakianiGovind Bhagat
Aug 9, 2019·The American Journal of Dermatopathology·Andréia Neves Comodo-NavarroGilles Landman
Oct 3, 2018·Case Reports in Hematology·Amy G StarrChaitra S Ujjani
Mar 2, 2019·Critical Reviews in Oncology/hematology·Yazid BelkacemiNhu Hanh To
Apr 4, 2008·Archives of Pathology & Laboratory Medicine·Judith A Ferry
Jan 13, 2004·Clinical Lymphoma·Andrew P Grigg, Joseph M Connors

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Zhonghua wai ke za zhi [Chinese journal of surgery]
Q DingX Sun
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Catherine K ParkGeorge Lawrence
Laboratory Investigation; a Journal of Technical Methods and Pathology
Yoshihiko HoshidaK Aozasa
British Journal of Haematology
C PreudhommeP Fenaux
© 2022 Meta ULC. All rights reserved