Mutations of the human interferon alpha-2b (hIFN-α2b) gene in occupationally protracted low dose radiation exposed personnel

Cytokine
Saman ShahidNauman Ahmad

Abstract

Ionizing radiations impact human tissues by affecting the DNA bases which constitute genes. Human interferon alpha 2b gene synthesizes a protein which is an important anticancerous, immunomodulatory, anti-proliferative and antiviral protein. This study was aimed to identify interferon alpha-2b mutations as a consequence of the use of occupational chronic low dose radiation by hospital radiation exposed workers. A molecular analysis was done in which DNAs were extracted from blood samples from radiology, radiotherapy and nuclear medicine workers. The gene was amplified through polymerase chain reaction and further genetic data from sequencing results analyzed by bioinformatics tools in order to determine as to how mutations in interferon alpha 2b sequences will lead to changes in human interferon alpha-2b protein. A total of 41% gene mutations was detected among all radiation exposed workers in which higher percentage (5.4%) of base insertion mutations and 14% frameshift mutations were found in radiology workers. The chronic use of low dose of radiations by occupational workers has a significant correlation with mutational effects on interferon alpha 2b gene, further evident by depressed interferon alpha levels in serum. This ca...Continue Reading

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Citations

Jun 15, 2016·International Journal of Cancer. Journal International Du Cancer·Guozi YangJiuwei Cui
Jul 13, 2016·Cancer Biotherapy & Radiopharmaceuticals·Fayyaz AhmedTanveer Mustafa
Jun 28, 2019·Arhiv za higijenu rada i toksikologiju·Dauren BotbayevSabrina Angelini
May 12, 2017·Clinical and Experimental Medicine·Saman Shahid, Khalid Masood

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