Abstract
Expression of survivin, a member of the inhibitor-of-apoptosis (IAP) family, is elevated in fetal tissues and in various human cancers originating in the breast, lung, prostate, colon, pancreas, and stomach. Since overexpression of the survivin gene has been linked to poor patient survival in several cancers, survivin may be an important prognostic marker. Mechanisms up-regulating survivin gene expression in cancer are poorly understood. Recently, wild-type p53 was found to repress expression of the survivin gene by binding to the survivin promoter, thereby inhibiting promoter activity. Further, loss of heterozygosity (LOH) at 17p13 distal to the p53 gene is associated with more aggressive behavior of breast cancers. We therefore tested the hypothesis that not only p53 gene mutation but also LOH at 17p13 can up-regulate survivin expression in breast cancer. Survivin mRNA expression was greater in cancers than in uninvolved tissues (p < 0.0001). Mutations of the p53 gene were detected in 5 of 25 tumors; higher survivin gene expression was evident in these. LOH at the D17S938 locus (17p13.1) was found in 10 of 25 tumors, and most of these also showed increased survivin gene expression. Thus expression of survivin may be regulated...Continue Reading
References
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P M HollandD H Gelfand
Aug 24, 1990·Cell·D MichalovitzM Oren
Feb 1, 1988·Molecular and Cellular Biology·C A FinlayA J Levine
May 1, 1994·Human Pathology·S M KennedyN K Spurr
Dec 1, 1996·The Journal of Pathology·D T LeahyN A Parfrey
May 15, 1997·Nature·Y HauptM Oren
Aug 1, 1997·Nature Medicine·G AmbrosiniD C Altieri
Mar 30, 1999·Experimental Cell Research·M Jäättelä
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MonzóA Abad
Nov 24, 1999·The American Journal of Medicine·P SaikumarM A Venkatachalam
Apr 15, 2000·Gut·A I SarelaP J Guillou
Nov 28, 2000·Japanese Journal of Cancer Research : Gann·K AsanumaN Watanabe
Dec 5, 2000·Cancer Genetics and Cytogenetics·V LaunonenR Winqvist
Feb 15, 2001·Biochemistry·S ShinB H Oh
Jul 6, 2001·The Journal of Pathology·S SeitzS Scherneck
Nov 21, 2001·The Journal of Biological Chemistry·William H HoffmanMaureen Murphy
Jan 10, 2003·Cancer Detection and Prevention·William L HoYi-Ching Wang
Citations
Jul 11, 2006·Breast Cancer Research and Treatment·Lida KostadimaNicholas Pavlidis
Oct 21, 2005·The Journal of Molecular Diagnostics : JMD·Matthias WoenckhausWolfgang Dietmaier
Aug 14, 2010·Cancer Gene Therapy·Y ShaoD Q Xu
Jan 30, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Aziza NassarCynthia Cohen
Feb 28, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Aziza NassarCynthia Cohen
May 19, 2010·Biomarkers in Medicine·Hirendra Nath Banerjee, Mukesh Verma
Mar 16, 2012·Haematologica·Akira YoshidaTakanori Ueda
Oct 22, 2011·International Journal of Molecular Sciences·Wei Zhang, Yingyan Yu
Feb 7, 2007·Future Oncology·Cheng-long HuangAkira Miyatake
Feb 22, 2011·Surgical Oncology·Kumkum JhaManoj Pandey
Jan 23, 2008·American Journal of Clinical Pathology·Samia GonzalezXavier Leroy
Feb 3, 2007·Cancer Science·Saori KoshidaNaoki Watanabe
Jul 19, 2006·Oncogene·F VégranS Lizard-Nacol
Aug 26, 2016·Breast Cancer : Basic and Clinical Research·David N Danforth
Mar 22, 2018·Oncotarget·Paulina Cerda-OpazoAndrew F G Quest
May 3, 2006·Cancer Research·Km Wahidur RahmanFazlul H Sarkar
Jul 11, 2007·Molecular Cancer Therapeutics·Ellen WeisbergJames D Griffin
Jan 13, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B M RyanM J Duffy