Mar 2, 2020

Mutations, Recombination and Insertion in the Evolution of 2019-nCoV

BioRxiv : the Preprint Server for Biology
Aiping WuGenhong Cheng

Abstract

Background: The 2019 novel coronavirus (2019-nCoV or SARS-CoV-2) has spread more rapidly than any other betacoronavirus including SARS-CoV and MERS-CoV. However, the mechanisms responsible for infection and molecular evolution of this virus remained unclear. Methods: We collected and analyzed 120 genomic sequences of 2019-nCoV including 11 novel genomes from patients in China. Through comprehensive analysis of the available genome sequences of 2019-nCoV strains, we have tracked multiple inheritable SNPs and determined the evolution of 2019-nCoV relative to other coronaviruses. Results: Systematic analysis of 120 genomic sequences of 2019-nCoV revealed co-circulation of two genetic subgroups with distinct SNPs markers, which can be used to trace the 2019-nCoV spreading pathways to different regions and countries. Although 2019-nCoV, human and bat SARS-CoV share high homologous in overall genome structures, they evolved into two distinct groups with different receptor entry specificities through potential recombination in the receptor binding regions. In addition, 2019-nCoV has a unique four amino acid insertion between S1 and S2 domains of the spike protein, which created a potential furin or TMPRSS2 cleavage site. Conclusions: ...Continue Reading

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Mentioned in this Paper

Subgroup
Single Nucleotide Polymorphism
Middle East Respiratory Syndrome (Mers)
Study
Biological Evolution
Base Sequence
Protein Domain
Spike protein, human
Betacoronavirus
Protein Binding Motif

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