Mutations that alter the helix-turn-helix region of the spollAC protein: a Bacillus subtilis sporulation-specific sigma factor

Molecular Microbiology
M D YudkinL Appleby

Abstract

It has previously been shown that spollAC561, a mutation that diminishes the incidence of sporulation by more than six orders of magnitude, alters the residue at position 13 of the helix-turn-helix region of the sporulation-specific sigma factor encoded by spollAC from valine to methionine (Yudkin, 1987b). We have now found that four spontaneous revertants, which sporulate at an incidence of 30-60%, all contain transitions within the codon that was altered by spo-561. The mutant methionine is replaced by isoleucine in two revertants, and by threonine in the other two.

References

Jan 1, 1988·Annual Review of Biochemistry·J D Helmann, M J Chamberlin
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H L Carter, C P Moran
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S Tabor, C C Richardson
Oct 1, 1987·Protein Engineering·M D Yudkin
Apr 6, 1987·Nature·J E AndersonS C Harrison

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Citations

Mar 1, 1995·Microbiological Reviews·W G Haldenwang

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