Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans.

Genetics
E C Park, H R Horvitz

Abstract

We have analyzed 31 mutations that have dominant effects on the behavior or morphology of the nematode Caenorhabditis elegans. These mutations appear to define 15 genes. We have studied ten of these genes in some detail and have been led to two notable conclusions. First, loss of gene function for four of these ten genes results in a wild-type phenotype; if these genes represent a random sample from the genome, then we would estimate that null mutations in about half of the genes in C. elegans would result in a nonmutant phenotype. Second, the dominant effects of mutations in nine of these ten genes are caused by novel gene functions, and in all nine cases the novel function is antagonized by the wild-type function.

Citations

Mar 17, 2017·Open Biology·Ralf J SommerMichael S Werner
Oct 29, 2011·The Journal of Biological Chemistry·Ping LiuZhao-Wen Wang
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Natasha P DegtyarevaThomas D Petes
Jan 24, 2006·Nature Genetics·Yoshio IkedaLaura P W Ranum
Nov 11, 2006·Annual Review of Genetics·William F Schafer
Jul 8, 2008·PLoS Genetics·Todd R GruningerL Rene Garcia
Sep 20, 2007·Current Biology : CB·Kenneth R Norman, Andres Villu Maricq
Jul 16, 2004·The Journal of Physiology·Maëlle Jospin, Bruno Allard
Oct 14, 1998·Trends in Genetics : TIG·J Hodgkin, R K Herman
Jul 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christina I PetersenJeffrey R Balser
Oct 19, 2007·PLoS Genetics·Brigitte LeBoeufL Rene Garcia
Oct 19, 2007·BMC Neuroscience·George D Tsibidis, Nektarios Tavernarakis
Sep 24, 2004·Physiological Reviews·Popi Syntichaki, Nektarios Tavernarakis
Jan 30, 2008·The Journal of Cell Biology·Paolo M MangahasZheng Zhou
Jun 30, 2006·Journal of Neurogenetics·David J ReinerL Rene Garcia
May 1, 1992·Nature Genetics·R WaterstonN Halloran
Jan 1, 1995·Life Sciences·A C Bowling, M F Beal
Sep 3, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·I Mano, M Driscoll
May 17, 2000·The Journal of Cell Biology·M HammarlundE M Jorgensen
Jan 1, 1997·Annual Review of Physiology·N Tavernarakis, M Driscoll
Apr 25, 2008·Molecular Biology of the Cell·Denise K ChunJoshua M Kaplan
Sep 16, 2006·The Journal of Biological Chemistry·Bryan T CarrollPhil G Morgan
Feb 27, 1999·Toxicology Letters·B KayserM M Sedensky
Jul 31, 2007·Current Biology : CB·Bojun ChenZhao-Wen Wang

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