Mutator dynamics in fluctuating environments

Proceedings. Biological Sciences
J M J Travis, E R Travis

Abstract

Populations with high mutation rates (mutator clones) are being found in increasing numbers of species, and a clear link is being established between the presence of mutator clones and drug resistance. Mutator clones exist despite the fact that in a constant environment most mutations are deleterious, with the spontaneous mutation rate generally held at a low value. This implies that mutator clones have an important role in the adaptation of organisms to changing environments. Our study examines how mutator dynamics vary according to the frequency of environmental fluctuations. Although recent studies have considered a single environmental switch, here we investigate mutator dynamics in a regularly varying environment, seeking to mimic conditions present, for example, under certain drug or pesticide regimes. Our model provides four significant new insights. First, the results demonstrate that mutators are most prevalent under intermediate rates of environmental change. When the environment oscillates more rapidly, mutators are unable to provide sufficient adaptability to keep pace with the frequent changes in selection pressure and, instead, a population of 'environmental generalists' dominates. Second, our findings reveal that...Continue Reading

References

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J W Drake
Jan 1, 1971·Journal of Molecular Evolution·T Ota, M Kimura
Jan 1, 1971·Journal of Molecular Evolution·T Ota
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·I P TomlinsonW F Bodmer
Jan 1, 1997·Journal of Bacteriology·E F MaoJ H Miller
Jun 12, 1997·Nature·F TaddeiB Godelle
Feb 21, 1998·Proceedings. Biological Sciences·D J EarnB T Grenfell
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·O TenaillonF Taddei
Nov 14, 2000·Trends in Genetics : TIG·L M Mansky, K S Cunningham
Nov 21, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P D SniegowskiA Shaver
May 1, 1997·Trends in Ecology & Evolution·P Rohani, D J Earn
May 1, 1981·Evolution; International Journal of Organic Evolution·John H Gillespie

❮ Previous
Next ❯

Citations

Sep 4, 2012·Bulletin of Mathematical Biology·Benjamin Allen, Daniel I Scholes Rosenbloom
Aug 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·David J Earl, Michael W Deem
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sandra TrindadeIsabel Gordo
Sep 25, 2003·Antimicrobial Agents and Chemotherapy·Patricia Komp LindgrenDiarmaid Hughes
Nov 2, 2004·Journal of Bacteriology·Shouan Zhang, George W Sundin
Apr 27, 2004·Artificial Life·Ye Li, Claus O Wilke
Jan 18, 2013·PLoS Genetics·Alejandro CouceJesús Blázquez
Jun 23, 2010·PloS One·Michael StichEster Lázaro
May 25, 2006·International Journal of Hematology·Kazuo Kinoshita, Taichiro Nonaka
Sep 15, 2005·Genetics·Jean-Baptiste André, Bernard Godelle
Feb 21, 2006·Genetics·Michael E Palmer, Marc Lipsitch
Jan 21, 2009·Genetics·C Scott WylieHerbert Levine
Jun 10, 2011·Genetics·Michael M Desai, Daniel S Fisher
Dec 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sébastien WielgossDominique Schneider
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael W Deem
Apr 18, 2014·The American Naturalist·Daniel I S Rosenbloom, Benjamin Allen
Nov 13, 2009·Medical Hypotheses·B Brutovsky, D Horvath
Sep 1, 2009·Journal of Theoretical Biology·Adam Lampert, Tsvi Tlusty
Oct 29, 2015·Genome Biology and Evolution·Ximiao HeCharles Vinson
May 9, 2006·Molecular Microbiology·Erick Denamur, Ivan Matic
Aug 1, 2008·Evolutionary Applications·Carol Eunmi Lee, Gregory William Gelembiuk
May 29, 2004·Trends in Microbiology·Olivier TenaillonIvan Matic
Oct 20, 2012·FEMS Microbiology Reviews·Carolina Díaz Arenas, Tim F Cooper
May 4, 2018·Journal of Virology·Kayla M Peck, Adam S Lauring
Jan 11, 2005·Nature Reviews. Genetics·John F Y Brookfield
Jan 27, 2007·The American Journal of Surgical Pathology·Parul BhargavaWilliam D Travis
Apr 27, 2007·The American Journal of Surgical Pathology·Sanjay Mukhopadhyay, Anna-Luise A Katzenstein
Aug 28, 2007·Journal of Thoracic Imaging·Jeffrey P KanneNestor L Müller
Feb 20, 2019·Pathology International·Shojiro IchimataSatoshi Shiozawa
Jun 30, 2010·Histopathology·Saral DesaiAndrew G Nicholson
Dec 20, 2005·Histopathology·J L Hornick, C D M Fletcher
Nov 28, 2007·Annual Review of Pathology·Jeffery K Taubenberger, David M Morens
Jul 7, 2010·The British Journal of Radiology·A Sperb RubinG Zanetti
Oct 11, 2014·Reports on Progress in Physics·E Kussell, M Vucelja
Mar 11, 2020·PLoS Biology·Ricardo S RamiroIsabel Gordo
Dec 24, 2008·Animal Health Research Reviews·Patrick Boerlin, Richard J Reid-Smith
Sep 21, 2016·Genetics·Benjamin H Good, Michael M Desai
Apr 18, 2017·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Paweł BłażejPaweł Mackiewicz
Jan 15, 2019·Critical Reviews in Food Science and Nutrition·K Srinivasan, Elna M Buys

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.