MutS HOMOLOG1-derived epigenetic breeding potential in tomato

Plant Physiology
Xiaodong YangSally A Mackenzie

Abstract

Evidence is compelling in support of a naturally occurring epigenetic influence on phenotype expression in land plants, although discerning the epigenetic contribution is difficult. Agriculturally important attributes like heterosis, inbreeding depression, phenotypic plasticity, and environmental stress response are thought to have significant epigenetic components, but unequivocal demonstration of this is often infeasible. Here, we investigate gene silencing of a single nuclear gene, MutS HOMOLOG1 (MSH1), in the tomato (Solanum lycopersicum) 'Rutgers' to effect developmental reprogramming of the plant. The condition is heritable in subsequent generations independent of the MSH1-RNA interference transgene. Crossing these transgene-null, developmentally altered plants to the isogenic cv Rutgers wild type results in progeny lines that show enhanced, heritable growth vigor under both greenhouse and field conditions. This boosted vigor appears to be graft transmissible and is partially reversed by treatment with the methylation inhibitor 5-azacytidine, implying the influence of mobile, epigenetic factors and DNA methylation changes. These data provide compelling evidence for the feasibility of epigenetic breeding in a crop plant.

Citations

Feb 11, 2016·Functional & Integrative Genomics·Ali SoltaniShahryar F Kianian
Mar 6, 2016·Journal of Experimental Botany·Andriy Bilichak, Igor Kovalchuk
Apr 3, 2016·Free Radical Biology & Medicine·Katie L LiberatoreShahryar F Kianian
Nov 8, 2016·In Vitro Cellular & Developmental Biology. Plant : Journal of the Tissue Culture Association·Paul Chavarriaga-AguirreJoe Tohme
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ian K GreavesElizabeth S Dennis
Mar 21, 2018·BMC Genomics·Quentin Gouil, David C Baulcombe
May 30, 2019·Cold Spring Harbor Perspectives in Biology·Xiaodong Yang, Sally A Mackenzie
Dec 4, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sally A Mackenzie, Hardik Kundariya
Feb 14, 2020·Genome Génome / Conseil National De Recherches Canada·Mark A A Minow, Joseph Colasanti
Mar 24, 2018·Plant Biotechnology Journal·Sunil K Kenchanmane RajuSally Mackenzie
Jun 28, 2019·Plant Direct·Sunil Kumar Kenchanmane RajuSally Mackenzie
Apr 13, 2020·Journal of Experimental Botany·Serena VarottoDragana Miladinović
Dec 29, 2020·Journal of Plant Physiology·Federico ScossaAlisdair R Fernie
Oct 23, 2020·Functional & Integrative Genomics·Gaurav AgarwalRajeev K Varshney
Apr 2, 2021·Journal of Agricultural and Food Chemistry·Karthika VVemanna S Ramu
Mar 12, 2021·The New Phytologist·Isaac J DoppSally A Mackenzie
Jul 10, 2021·Frontiers in Genetics·Aamir RainaRais A Ganai
Aug 28, 2021·Biology·Ioanna KakoulidouStéphane Maury

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