Mutual inactivation of valinomycin and protonophores by complex formation in liposomal membranes

FEBS Letters
G Krishnamoorthy


The stimulation presence of a protonophore [3,5-di(ter-butyl)-4-hydroxybenzylidenemalononitrile or carbonyl cyanide m-chlorophenylhydrazone] and valinomycin in a liposome suspension results in time-dependent inactivation of ion transport by both the protonophore and valinomycin. Correlation of the inactivation with spectrophotometric observations on the formation of a complex between the protonophore and valinomycin strongly suggests that the complex observed has no (or very low) activity for the transport of either H+ or K+. The stoichiometry of valinomycin and the protonophore in the inactive complex is shown to be 1:1.


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Apr 15, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Stephen J MoorePhilip A Gale
Nov 26, 2010·Chemical Communications : Chem Comm·Stephen J MoorePhilip A Gale

Related Concepts

Carbonyl Cyanide m-Chlorophenyl Hydrazone
Drug Interactions
Hydrogen-Ion Concentration

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