Mutual recognition of TNT using antibodies polymeric shell having CdS

Talanta
Ridvan SayArzu Ersöz

Abstract

Click chemistry is the latest strategy called upon in the development of state of the art exponents of bioconjugation. In this study, we have proposed a covalent and photosensitive crosslinking conjugation of the antibody on nano-structures. For this purpose, quantum dots (QDs) without affecting conformation and function of proteins through the ruthenium-chelate based aminoacid monomer linkages have been applied. The aminoacid-monomer linkages called ANADOLUCA (AmiNoAcid Decorated and Light Underpining Conjugation Approach) give reusable oriented and cross-linked anti 2,4,6-trinitrotoluene (TNT) conjugated QD for TNT detection. In this work, a new and simple method has improved to design and prepare high sensitive nanoconjugates for TNT determination. We have demonstrated the use of luminescent QDs conjugated to antibody for the specific detection of the explosive TNT in aqueous environments. The binding affinity of each nanoconjugates for TNT detection by using Langmuir adsorption methods has also been investigated.

References

Apr 14, 2005·Chemical Reviews·Nathaniel L Rosi, Chad A Mirkin
May 5, 2005·Journal of the American Chemical Society·Ellen R GoldmanHedi Mattoussi
Apr 25, 2006·Biochemical and Biophysical Research Communications·Chenjie XuJianghong Rao
Nov 7, 2006·Molecular and Cellular Probes·Nathaniel C CadyCarl A Batt
Aug 10, 2007·Biomaterials·Timothy JamiesonAlexander M Seifalian
Aug 11, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A F E HezingerA Göpferich
Sep 18, 2007·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Guo Hua ShiTian Cai Zhang
May 23, 2008·Advanced Drug Delivery Reviews·Andrew M SmithShuming Nie
Aug 29, 2009·Analytical and Bioanalytical Chemistry·Manuela F Frasco, Nikos Chaniotakis

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Citations

Oct 20, 2012·Biosensors & Bioelectronics·Francesc A Esteve-Turrillas, Antonio Abad-Fuentes
Apr 10, 2019·Journal of Fluorescence·Sibel BüyüktiryakiArzu Ersöz

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