Mutual regulation of decapentaplegic and hedgehog during the initiation of differentiation in the Drosophila retina

Developmental Biology
E R Borod, U Heberlein

Abstract

Neuronal differentiation in the Drosophila retinal primordium, the eye imaginal disc, begins at the posterior tip of the disc and progresses anteriorly as a wave. The morphogenetic furrow (MF) marks the boundary between undifferentiated anterior cells and differentiating posterior cells. Anterior progression of differentiation is driven by Hedgehog, synthesized by cells located posterior to the MF. We report here that hedgehog (hh), which is expressed prior to the start of differentiation along the disc's posterior margin, also plays a crucial role in the initiation of differentiation. Using a temperature-sensitive allele we show that hh is normally required at the posterior margin to maintain the expression of decapentaplegic (dpp) and of the proneural gene atonal. In addition, we find that ectopic differentiation driven by ectopic dpp expression or loss of wingless function requires hh. Consistent with this is our observation that ectopic dpp induces the expression of hh along the anterior margin even in the absence of differentiation. Taken together, these data reveal a novel positive regulatory loop between dpp and hh that is essential for the initiation of differentiation in the eye disc.

References

Oct 15, 1976·Developmental Biology·D F ReadyS Benzer
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J A KassisN Perrimon
Oct 30, 1980·Nature·C Nüsslein-Volhard, E Wieschaus
Feb 26, 1998·Current Topics in Developmental Biology·J E Treisman, U Heberlein
Apr 1, 1987·Developmental Biology·A Tomlinson, D F Ready

❮ Previous
Next ❯

Citations

Oct 22, 2003·Developmental Biology·Ting ChangVolker Hartenstein
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·C K Chen, C T Chien
Jun 15, 2007·Developmental Biology·Chan-Yen OuCheng-Ting Chien
Jun 1, 2014·Developmental Biology·Vilaiwan M FernandesEsther M Verheyen
Aug 6, 2010·Arthropod Structure & Development·Sophie MuratAlistair P McGregor
Sep 15, 2016·PLoS Computational Biology·Patrick FriedDagmar Iber
Jun 1, 2015·Developmental Biology·Carla M VillarrealYuichiro Suzuki
Jun 2, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Aloma B Rodrigues, Kevin Moses
Sep 5, 2002·The Journal of Experimental Zoology·Matthew P HarrisRichard O Prum
Feb 11, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·María Domínguez, Fernando Casares
Sep 10, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Jessica E Treisman
Feb 11, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kristin RoedererJustin P Kumar
Nov 21, 2001·Nature Reviews. Genetics·J P Kumar
Sep 21, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Maria Tsachaki, Simon G Sprecher
May 14, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Fernando Casares, Alistair P McGregor
May 21, 2003·Development·Kartik S PappuGraeme Mardon
Oct 6, 2006·Development·Catarina Bras-PereiraFernando Casares
Dec 2, 2004·Developmental Cell·Clarissa A Henry, Sharon L Amacher
Jul 11, 2021·Developmental Biology·Ruth I Johnson
Jun 26, 2007·Developmental Biology·Janghoo LimKwang-Wook Choi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.