Mutual regulatory interactions of the trunk gap genes during blastoderm patterning in the hemipteran Oncopeltus fasciatus

Developmental Biology
Jonathan Ben-David, Ariel D Chipman

Abstract

The early embryo of the milkweed bug, Oncopeltus fasciatus, appears as a single cell layer - the embryonic blastoderm - covering the entire egg. It is at this blastoderm stage that morphological domains are first determined, long before the appearance of overt segmentation. Central to the process of patterning the blastoderm into distinct domains are a group of transcription factors known as gap genes. In Drosophila melanogaster these genes form a network of interactions, and maintain sharp expression boundaries through strong mutual repression. Their restricted expression domains define specific areas along the entire body. We have studied the expression domains of the four trunk gap gene homologues in O. fasciatus and have determined their interactions through dsRNA gene knockdown experiments, followed by expression analyses. While the blastoderm in O. fasciatus includes only the first six segments of the embryo, the expression domains of the gap genes within these segments are broadly similar to those in Drosophila where the blastoderm includes all 15 segments. However, the interactions between the gap genes are surprisingly different from those in Drosophila, and mutual repression between the genes seems to play a much less...Continue Reading

References

Jun 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Hülskamp, D Tautz
Nov 1, 1996·Trends in Genetics : TIG·R Rivera-Pomar, H Jäckle
Jan 1, 1997·International Review of Cytology·B T Rogers, T C Kaufman
Nov 10, 2001·Development Genes and Evolution·A Minelli
Dec 1, 2001·Annual Review of Entomology·Gregory K Davis, Nipam H Patel
Sep 28, 2002·Trends in Genetics : TIG·Frietson GalisJohan A J Metz
Sep 15, 2004·Developmental Cell·Diethard Tautz
Sep 24, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Andrew Peel
Mar 1, 2005·Evolution & Development·Gregor BucherMartin Klingler
Nov 11, 2005·Development·Alexander C CernyMartin Klingler
Dec 13, 2005·Evolution & Development·Paul Z Liu, Thomas C Kaufman
Dec 13, 2005·Nature Reviews. Genetics·Andrew D PeelMichael Akam
Feb 8, 2006·Developmental Biology·Kristen A PanfilioThomas C Kaufman
Feb 14, 2006·Science·Eric H Davidson, Douglas H Erwin
Jan 25, 2008·Development·Henrique Marques-SouzaDiethard Tautz
Jan 14, 2009·Nature Reviews. Genetics·Douglas H Erwin, Eric H Davidson

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Citations

Oct 12, 2010·Cellular and Molecular Life Sciences : CMLS·Johannes Jaeger
Mar 16, 2013·Molecular Biology and Evolution·Tal Naggan PerlAriel D Chipman
Sep 29, 2012·Evolution & Development·Michael BirkanAriel D Chipman
Jun 11, 2011·Developmental Biology·Ralf JanssenWim G M Damen
Oct 7, 2016·Proceedings. Biological Sciences·Reut Stahi, Ariel D Chipman
Oct 12, 2016·Arthropod Structure & Development·Ralf Janssen
Apr 23, 2017·Genesis : the Journal of Genetics and Development·Ariel D Chipman
Apr 23, 2017·Genesis : the Journal of Genetics and Development·Neta GinzburgAriel D Chipman
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Xin ZhuEzzat El-Sherif
Apr 23, 2017·Development·Tzach AumanAriel D Chipman
Sep 29, 2017·Integrative and Comparative Biology·Tzach Auman, Ariel D Chipman
Sep 7, 2020·Developmental Biology·Asya V NovikovaAriel D Chipman

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