PMID: 6168893Jan 1, 1981Paper

Mutual relationship between antibiotics and resting spores of Bacillus subtilis: morphological changes and macromolecular synthesis after germination of spores treated with cyclic polypeptide and aminoglycoside antibiotics

Microbiology and Immunology
Y HayakawaS Kozuka

Abstract

Morphological changes and synthesis of DNA, RNA, protein, and cell wall were investigated during germination of resting spores of Bacillus subtilis exposed transiently to the cyclic polypeptide antibiotics, polymyxin B and gramicidin S, and the aminoglycoside antibiotics, streptomycin, kanamycin, and gentamicin. Normal germinated spores showed breaks of the spore coat, a diminution in size and a fibrillar appearance of the cortex, a swelling core, a cell wall as thick as that of vegetable cells, some mesosomes and DNA fibrils. On the other hand, no breaks of the spore coat, a spore core with a slight swelling and irregular form, a thin cell wall, no demonstration of the nuclear material and no granularity in the cytoplasm were characteristic of the germinated spores derived from polymyxin B- and gramicidin S-treated resting spores. With gramicidin S-treated germinated spores a few vacuoles were formed in the cytoplasm. Both polymyxin B- and gramicidin S-treated germinated spores showed little or no synthesis of DNA, RNA, and protein. The vegetative cells derived from streptomycin-treated resting spores demonstrated several finely granular regions in the cytoplasm and a disorder of the fibrillar nucleoid, and their autolysis occ...Continue Reading

References

Nov 1, 1974·Journal of Ultrastructure Research·M Fooke-AchterrathB Menge
Jan 1, 1969·Journal of Bacteriology·M KoikeT Matsuo
Jun 1, 1968·Klinische Wochenschrift·P Giesbrecht, H Ruska
Jan 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R L Armstrong, N Sueoka
Jul 1, 1970·Journal of Bacteriology·M L Higgins, G D Shockman

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Citations

Jan 1, 1990·Microbiology and Immunology·Y FujitaK Tochikubo
Apr 1, 1990·Clinical Microbiology Reviews·A D Russell

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