Mutual remodeling and conformation grid: a mediator code?

Structure
Peter A Meyer, Jianhua Fu

Abstract

How does a common RNA polymerase II apparatus generate a complex pattern of transcripts in response to many gene-specific transcription factors and in accordance with cell's state? In this issue of Structure, Cai et al. reveal that the process involves coordinated conformational changes in Pol II and Mediator.

References

Sep 28, 1999·Cell·J FuR D Kornberg
Sep 6, 2002·Biochimica Et Biophysica Acta·Averell Gnatt
May 18, 2005·Trends in Biochemical Sciences·Roger D Kornberg
Dec 20, 2008·PLoS Computational Biology·Agnes Tóth-PetróczyMonika Fuxreiter
Apr 17, 2009·Structure·Ronald C Conaway, Joan Weliky Conaway
Apr 17, 2009·Structure·Gang CaiFrancisco J Asturias
Oct 21, 2009·Nature Chemical Biology·David D BoehrPeter E Wright
Feb 16, 2010·Nature Structural & Molecular Biology·Gang CaiFrancisco J Asturias
Mar 20, 2010·Trends in Biochemical Sciences·Dylan J Taatjes
Jul 5, 2011·Nature·Tsuyoshi ImasakiYuichiro Takagi
Sep 16, 2011·The Biochemical Journal·Chung-Jung Tsai, Ruth Nussinov
May 15, 2012·Structure·Gang CaiFrancisco J Asturias

❮ Previous
Next ❯

Citations

Sep 6, 2013·Nucleic Acids Research·Sarah K LeeLaurie A Stargell
Jan 25, 2014·The Plant Journal : for Cell and Molecular Biology·Yan YangLi-Jia Qu
Sep 18, 2012·Biochimica Et Biophysica Acta·Grant A Hartzog, Jianhua Fu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.