Mutually Exclusive Cellular Uptake of Combinatorial Supramolecular Copolymers

Chemistry : a European Journal
Sam van DunLuc Brunsveld

Abstract

The cellular uptake of self-assembled biological and synthetic matter results from their multicomponent properties. However, the interplay of the building block composition of self-assembled materials and uptake mechanisms urgently requires addressing. It is shown here that supramolecular polymers that self-assemble in aqueous media, are a modular and controllable platform to modulate cellular delivery by the introduction of small ligands or cationic moieties, with concomitantly different cellular uptake kinetics and valence dependence. A library of supramolecular copolymers revealed stringent mutually exclusive uptake behavior in which either of the uptake pathways dominated, with sharp compositional transition. Supramolecular biomaterial engineering thus provides for adaptive platforms with great potential for efficient tuning of multivalent and multicomponent systems interfacing with biological matter.

References

Dec 13, 2001·Chemical Reviews·L BrunsveldR P Sijbesma
Aug 19, 2003·Biomaterials·Ulrich HerselHorst Kessler
Apr 11, 2008·Chemical Communications : Chem Comm·You-Rim YoonMyongsoo Lee
Mar 5, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Lucie SanceyColl Jean-Luc
Mar 19, 2009·Angewandte Chemie·Marion K Müller, Luc Brunsveld
Oct 17, 2009·The Journal of Biological Chemistry·Chen-Yu JiaoSandrine Sagan
Aug 24, 2010·Chemical Communications : Chem Comm·Marion K MüllerLuc Brunsveld
Mar 31, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Golam KibriaHideyoshi Harashima
Jul 15, 2011·BMC Cancer·Aliakbar TaherianThomas A Haas
Aug 5, 2011·Accounts of Chemical Research·Wafa' T Al-Jamal, Kostas Kostarelos
May 1, 2012·Journal of the American Chemical Society·Katja Petkau-MilroyLuc Brunsveld
Jun 13, 2012·Angewandte Chemie·Anna Barnard, David K Smith
Sep 7, 2012·Angewandte Chemie·Carlo FastingRainer Haag
Apr 3, 2013·Journal of the American Chemical Society·Ji-Hun SeoNobuhiko Yui
Sep 7, 2013·The Journal of Physical Chemistry. B·Libo LiToby W Allen
Oct 12, 2013·Chembiochem : a European Journal of Chemical Biology·Katharina KoschekJörg Rademann
Apr 1, 2014·Chemical Society Reviews·Jenny BrinkmannPascal Jonkheijm
Jun 2, 2015·Chemical Communications : Chem Comm·Giulio GaspariniStefan Matile
Dec 15, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Catherine A FromenJoseph M DeSimone
Jan 27, 2016·ACS Nano·Maarten H BakkerLorenzo Albertazzi
Oct 7, 2016·Chemical Society Reviews·Christopher D Jones, Jonathan W Steed
Jan 18, 2017·Accounts of Chemical Research·Bastiaan C Buddingh', Jan C M van Hest
Jun 7, 2017·Chemical Society Reviews·Shahed BehzadiMorteza Mahmoudi
Aug 23, 2017·Chemical Society Reviews·Matthew J Webber, Robert Langer
Oct 11, 2017·Chemical Society Reviews·Olga J G M GoorE W Meijer
Feb 20, 2018·Angewandte Chemie·Miguel Ángel Alemán GarcíaLuc Brunsveld

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Citations

Jan 15, 2021·Angewandte Chemie·Jurgen SchillLuc Brunsveld
Mar 13, 2019·Bioconjugate Chemistry·Sjors P W WijnandsMaarten Merkx
May 2, 2020·Journal of the American Chemical Society·Eva Magdalena EstiradoLuc Brunsveld
Oct 18, 2019·Journal of the American Chemical Society·Eva Magdalena EstiradoLuc Brunsveld

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Methods Mentioned

BETA
fluorescence spectroscopy
dynamic light scattering
Flow cytometry
FACS
confocal microscopy
confocal

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