MutY-glycosylase: an overview on mutagenesis and activities beyond the GO system

Mutation Research
Ana Helena Sales de OliveiraLucymara Fassarella Agnez-Lima

Abstract

MutY is a glycosylase known for its role in DNA base excision repair (BER). It is critically important in the prevention of DNA mutations derived from 7,8-dihydro-8-oxoguanine (8-oxoG), which are the major lesions resulting from guanine oxidation. MutY has been described as a DNA repair enzyme in the GO system responsible for removing adenine residues misincorporated in 8-oxoG:A mispairs, avoiding G:C to T:A mutations. Further studies have shown that this enzyme binds to other mispairs, interacts with several enzymes, avoids different transversions/transitions in DNA, and is involved in different repair pathways. Additional activities have been reported for MutY, such as the repair of replication errors in newly synthesized DNA strands through its glycosylase activity. Moreover, MutY is a highly conserved enzyme present in several prokaryotic and eukaryotic organisms. MutY defects are associated with a hereditary colorectal cancer syndrome termed MUTYH-associated polyposis (MAP). Here, we have reviewed the roles of MutY in the repair of mispaired bases in DNA as well as its activities beyond the GO system.

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Citations

Feb 10, 2016·Nucleic Acids Research·Mathieu Chauleau, Stewart Shuman
Oct 16, 2015·Proceedings of the National Academy of Sciences of the United States of America·Patricia L FosterHaixu Tang
May 23, 2016·Archives of Toxicology·Gunnar Damgård NielsenPeder Wolkoff
Jul 28, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Rafael Cançado de FariaDébora de Oliveira Lopes
Jan 15, 2017·Free Radical Biology & Medicine·Douglas M BandaSheila S David
Oct 1, 2019·Environmental and Molecular Mutagenesis·Frank S Fernández-SilvaRodrigo S Galhardo
Oct 12, 2017·Metallomics : Integrated Biometal Science·C WachnowskyJ A Cowan
Nov 24, 2020·Environmental and Molecular Mutagenesis·Francisco Napoleão Tulio Varela-BarcaSílvia Regina Batistuzzo de Medeiros

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