MXB inhibits murine cytomegalovirus

Virology
Ananda Ayyappan Jaguva VasudevanCarsten Münk

Abstract

The MX dynamin GTPases inhibit diverse viruses at early post-entry phases. While MXA acts antiviral against influenza viruses, the anti HIV-1 activity of MXB was discovered recently. Here, we have studied the antiviral effect of MX proteins on murine cytomegalovirus (MCMV). Our data demonstrate that human MXB but not other human or murine MX proteins inhibit MCMV propagation. Evidently, the viral protein expression was delayed and the viral DNA amount in nucleus was diminished in MXB expressing cells indicating an obstruction of nuclear entry. Of note, MCMV did not deplete MX proteins. Considering the role of capsid on HIV-1 sensitivity to MXB, MXB binding to tested MCMV capsids was not detected. Moreover, MCMV restriction occurred only when MXB contained both the nuclear localization signal and a functional GTPase domain. Hence, we propose a new mode of inhibition of MCMV by MXB that is conspicuously different from that of HIV-1.

Citations

Sep 28, 2018·Journal of Virology·Peter Staeheli, Otto Haller
Sep 3, 2020·Emerging Microbes & Infections·Zhen WangChen Liang
Sep 11, 2019·Journal of Clinical Medicine·Florian Full, Armin Ensser
Jan 11, 2020·Frontiers in Immunology·Caroline L AshleyBarry Slobedman
Sep 11, 2020·Journal of Virology·Fiona Steiner, Jovan Pavlovic
Sep 25, 2020·Journal of Virology·K E JohnsonV L Tarakanova
Feb 4, 2021·Viruses·Eva-Maria SchillingThomas Stamminger
Jun 4, 2019·Structure·Sarah Sierra SmagaYong Xiong
Apr 20, 2021·Frontiers in Microbiology·Elenia ToccafondiMatteo Negroni

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