MxB is an interferon-induced restriction factor of human herpesviruses

Nature Communications
Michel CrameriJovan Pavlovic

Abstract

The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, also designated Mx2) is a potent human herpesvirus restriction factor in the context of IFN. We demonstrate that ectopic MxB expression restricts a range of herpesviruses from the Alphaherpesvirinae and Gammaherpesvirinae, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), and Kaposi's sarcoma-associated herpesvirus (KSHV). MxB restriction of HSV-1 and HSV-2 requires GTPase function, in contrast to restriction of lentiviruses. MxB inhibits the delivery of incoming HSV-1 DNA to the nucleus and the appearance of empty capsids, but not the capsid delivery to the cytoplasm or tegument dissociation from the capsid. Our study identifies MxB as a potent pan-herpesvirus restriction factor which blocks the uncoating of viral DNA from the incoming viral capsid.

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Citations

Jun 22, 2018·Journal of Virology·Bin XuChen Liang
Jun 29, 2018·Journal of Virology·Mirjam SchillingGeorg Kochs
Sep 28, 2018·Journal of Virology·Peter Staeheli, Otto Haller
Oct 20, 2018·Journal of Virology·Dong-Rong YiShan Cen
Feb 28, 2020·Nature Communications·Hong CaoMark A McNiven
Sep 3, 2020·Emerging Microbes & Infections·Zhen WangChen Liang
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Sep 1, 2021·Current Opinion in Virology·Katinka DöhnerBeate Sodeik

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Methods Mentioned

BETA
GTPases
GTPase
nuclear translocation
fluorescence imaging
transfection
flow cytometry
reverse transcription PCR
confocal microscopy
transmission electron microscopy
Electrophoresis

Software Mentioned

Huygens
CellProfiler
multcomp
MultiGauge
FlowJo
KNIME
R
ImageJ

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