Mxi1 tumor suppressor gene is not mutated in primary pancreatic adenocarcinoma

Cancer Letters
D BartschP J Goodfellow

Abstract

Amplification of the c-myc oncogene occurs in a variety of solid tumors, including pancreatic adenocarcinomas. The MXI1 gene, located at 10q24-q25, may serve to negatively regulate c-myc oncogene activity, and potentially has tumor suppressor function. As such, altered MXI1 function might contribute to tumorigenesis. We examined 40 primary human pancreatic adenocarcinomas for MXI1 mutations. Single-strand conformation variant analysis and direct sequencing of the variants revealed a MXI1 polymorphism in 1 of 40 tumors. No MXI1 mutations were identified. Southern blot analyses did not reveal any gross rearrangements of MXI1. These results suggest that MXI1 is unlikely to play a role in human pancreatic adenocarcinoma tumorigenesis.

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Citations

Oct 19, 2002·Journal of Biomedical Science·C.V. Dang, B.C. Lewis
Jun 26, 1999·Biochimica Et Biophysica Acta·K P Foley, R N Eisenman
Jan 12, 2001·Molecular and Cellular Biology·T A Baudino, J L Cleveland
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May 22, 2008·British Journal of Cancer·J K R BoultC Tselepis
Dec 22, 1998·Molecular and Cellular Biology·C V Dang

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