Myasthenia gravis and specific immunotherapy: monoclonal antibodies

Annals of the New York Academy of Sciences
Xiao-Jun CaiZheng Jiao

Abstract

Myasthenia gravis (MG) is an acquired autoimmune disease affecting the postsynaptic membrane of neuromuscular junctions and characterized by antibody-mediated T cell dependence and complement involvement. Cholinesterase inhibitors (e.g., pyridostigmine bromide), glucocorticoids, and azathioprine are currently recommended as first-line treatments for MG, though they have limitations, including potential toxicity and ineffectiveness in patients with refractory MG. In recent years, owing to an increasing understanding of MG pathogenesis the development and execution of clinical trials with novel biologics, including monoclonal antibodies (mAbs) that have demonstrated higher safety and more specificity, provide new opportunities for the treatment of MG. In this article, we review recent advances in MG pathogenesis and the mAbs that have been used for target-specific MG therapy.

References

Nov 1, 1990·Clinical and Experimental Immunology·J A AarliR L Wollmann
Apr 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K Maruyama
Aug 14, 1998·Journal of the Neurological Sciences·P BongioanniA Muratorio
Apr 13, 1999·Archives of Neurology·G O SkeieN E Gilhus
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caishu DengPremkumar Christadoss
Dec 11, 2002·Journal of Autoimmunity·Rui-Sheng DuanBao-Guo Xiao
Nov 1, 2003·Annals of the New York Academy of Sciences·Geir Olve SkeieNils Erik Gilhus
Nov 18, 2003·Clinical and Experimental Dermatology·V J SwaleM H A Rustin
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erdem TüzünPremkumar Christadoss
Dec 30, 2004·Neurology·J RowinP Christadoss
Mar 16, 2005·Archives of Neurology·Fredrik RomiJohan Arild Aarli
Apr 26, 2005·Journal of Autoimmunity·Erdem TüzünPremkumar Christadoss
Sep 22, 2005·The American Journal of Chinese Medicine·Jae-Young UmHyung-Min Kim
Jul 25, 2006·Experimental Neurology·Henry J KaminskiFeng Lin
Aug 9, 2006·Neurology·E BartoccioniA Evoli
Mar 23, 2007·Acta Neurologica Scandinavica·M KakoulidouA K Lefvert
Jul 14, 2007·Protein and Peptide Letters·Meng LiYingqi Zhang
Dec 7, 2007·Muscle & Nerve·David GrobMurali Pagala
Jun 24, 2008·Annals of the New York Academy of Sciences·Rozen Le PanseSonia Berrih-Aknin
Jun 24, 2008·Annals of the New York Academy of Sciences·Premkumar ChristadossHuan Yang
Jun 24, 2008·Annals of the New York Academy of Sciences·Julie Rowin
Apr 18, 2009·Muscle & Nerve·Dominic B Fee, Edward J Kasarskis
Nov 13, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Stefan BlumRichard Wong
Jun 4, 2011·Journal of Autoimmunity·Erdem TüzünPremkumar Christadoss
Oct 20, 2011·Therapeutic Advances in Neurological Disorders·Richard J NowakJonathan M Goldstein
Dec 2, 2011·Clinical Pharmacology and Therapeutics·G J Dennis
Jan 6, 2012·Neurology·J Díaz-ManeraI Illa
Mar 28, 2012·Rheumatology International·Sooha KimMuhammad K Nisar
Dec 21, 2012·Neurology·Fulvio BaggiCarlo Antozzi
Mar 30, 2013·Autoimmunity Reviews·Erdem Tüzün, Premkumar Christadoss
Jul 10, 2013·Muscle & Nerve·Donald B SandersUNKNOWN Muscle Study Group
Jan 10, 2014·The New England Journal of Medicine·Valentin GoedeMichael Hallek
Jan 11, 2014·Journal of Autoimmunity·Angeline GradolattoSonia Berrih-Aknin
Feb 14, 2014·The New England Journal of Medicine·Jun-ichi NishimuraYuzuru Kanakura

❮ Previous
Next ❯

Citations

May 5, 2020·PharmacoEconomics·Erik LandfeldtHanns Lochmüller
May 9, 2021·Critical Reviews in Clinical Laboratory Sciences·Maria Alice V WillrichAshley Frazer-Abel
Jul 9, 2021·Neurological Research·Dejan Z AleksićDragana Lavrnić
Jul 7, 2021·Expert Opinion on Emerging Drugs·Deepak MenonVera Bril

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Clinical Drug Investigation
Lorenzo Maggi, Renato Mantegazza
Ryōikibetsu shōkōgun shirīzu
M Takamori
Nihon rinsho. Japanese journal of clinical medicine
N NakaoT Ibi
© 2021 Meta ULC. All rights reserved