PMID: 6169804Jan 1, 1981Paper

Myasthenia gravis: antibodies to acetylcholine receptor in ocular myasthenia gravis

Journal of Neurology
K Oda, Y Ito

Abstract

To improve the sensitivity of the radioimmunoassay method for anti-AChR-antibody, large amounts of sera from patients with myasthenia gravis, and higher concentrations of antigens and rabbit anti-human-IgG-antiserum, were used. These procedures enabled measurement of the titre value of over 0.04 pmol/ml serum and this value revealed a sensitivity about 10 times higher than that predicted using the previous model. Antibodies against AChR were found in 13 out of 17 ocular myasthenia patients (70%) and 35 of 37 with generalized myasthenia (90%). However, the average titre value of sera in those with ocular myasthenia was significantly lower than the value obtained in the generalized cases. Even in the patients with ptosis or ophthalmoparesis, in the early stage (less than one year) of ocular myasthenia, anti-AChR-antibodies were not detectable using this more sensitive assay method.

References

May 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·A K LefvertR Pirskanen
Jan 1, 1976·Annals of the New York Academy of Sciences·R R Almon, S H Appel
Feb 1, 1975·Archives of Neurology·S H HorowitzA E Papatestas
Oct 9, 1975·The New England Journal of Medicine·S H AppelN Levy

❮ Previous
Next ❯

Citations

Jul 1, 1985·Journal of the Neurological Sciences·H J OosterhuisT H The
Jan 1, 1981·Clinical Neurology and Neurosurgery·H J Oosterhuis
Aug 1, 1985·Journal of Neuroimmunology·S A RobbJ M Newsom-Davis
Jul 21, 1998·Annals of the New York Academy of Sciences·B M Conti-FineZ Y Wang
Apr 19, 2002·Annals of the New York Academy of Sciences·Henry J KaminskiHiroshi Mitsumoto
Dec 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·A Vincent, J Newsom-Davis
Aug 1, 1991·Italian Journal of Neurological Sciences·G TedeschiV Bonavita
Nov 1, 2003·Annals of the New York Academy of Sciences·Henry J KaminskiLinda Kusner
Nov 18, 2009·Muscle & Nerve·Jeffrey A AllenH Royden Jones
Jan 1, 1988·Acta Neurologica Scandinavica·A EvoliM Lo Monaco
Mar 1, 2005·Journal of Clinical Neuromuscular Disease·Hans D Katzberg, Vera Bril
Apr 16, 1984·Klinische Wochenschrift·I KaliesJ R Kalden
Nov 1, 1994·Survey of Ophthalmology·D A WeinbergT L Vollmer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.