Myasthenia gravis: disease severity and prognosis

Acta Neurologica Scandinavica. Supplementum
Fredrik RomiJohan Arild Aarli

Abstract

To examine myasthenia gravis (MG) severity and long-term prognosis in seronegative, seropositive, and thymoma MG. Four series of patients were studied retrospectively. Severity and treatment were assessed each year, and muscle antibodies were assayed. Seropositive MG patients had a more severe course than seronegative MG patients. MG severity was higher in non-thymectomized compared to thymectomized early-onset MG patients. MG severity did not differ between thymectomized and non-thymectomized late-onset patients. There was no significant difference in MG severity between thymoma and non-thymoma MG patients. MG is more severe in seropositive MG patients. With proper treatment, especially early thymectomy, the long-term prognosis is good in seropositive MG patients. The present studies indicate a benefit of thymectomy in early-onset MG, but no dramatic benefit in late-onset MG. Similar MG severity and outcome was seen in thymoma and non-thymoma MG.

References

Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F RomiJ A Aarli
Dec 4, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F RomiJ A Aarli
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Citations

Aug 5, 2011·Journal of Neurology·Alexandra PevznerStephan Kröger
Aug 28, 2012·Seminars in Thoracic and Cardiovascular Surgery·Victor Tomulescu, Irinel Popescu
Jan 1, 2008·Seminars in Thoracic and Cardiovascular Surgery·Shannon L Castle, Kemp H Kernstine
Oct 2, 2007·Clinical Neurology and Neurosurgery·Naoki KawaguchiTakamichi Hattori
Aug 30, 2014·Acta Neurologica Scandinavica·S YuB Bu
Mar 5, 2014·Acta Neurologica Scandinavica. Supplementum·J B AndersenN E Gilhus
May 2, 2009·Journal of Child Neurology·Paul GadientVinay Puri
Feb 7, 2019·Journal of Neurology·Seung Woo KimHa Young Shin
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Oct 30, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jeffrey T GuptillMatthew N Meriggioli
Apr 28, 2021·Neurology India·A S ShreedharaC Sarada

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