MYB fusions and CD markers as tools for authentication and purification of cancer stem cells from salivary adenoid cystic carcinoma

Stem Cell Research
A PanaccioneS V Ivanov

Abstract

Cancer stem cells (CSC) are considered the major cause of aggressive tumor behavior, recurrence, metastases, and resistance to radiation, making them an attractive therapeutic target. However, isolation of CSC from tumor tissue and their characterization are challenging due to uncertainty about their molecular markers and conditions for their propagation. Adenoid cystic carcinoma (ACC), which arises predominantly in the salivary glands, is a slow-growing but relentless tumor that frequently invades nerves and metastasizes. New effective treatment approaches for ACC have not emerged over the last 40years. Previously, based on a highly conserved SOX10 gene signature that we identified in the majority of ACC tumors, we suggested the existence in ACC of SOX10+ cells with neural stem properties and corroborated this hypothesis via isolation from ACC tissue a novel population of CSC, termed ACC-CSC. These cells activated NOTCH1 signaling and co-expressed SOX10 and other ACC-intrinsic neural crest stem cell markers with CD133, a CSC cell surface marker, suggesting that ACC is driven by a previously uncharacterized population of SOX10+/CD133+ cells with neural stem cell properties. Here, we authenticated ACC identity of our primary cul...Continue Reading

Citations

Sep 14, 2018·The Journal of Experimental Medicine·Joseph MandelbaumLeonard I Zon
Feb 12, 2019·Journal of Cellular Physiology·Maryam AkbarzadehNasser Samadi
Dec 15, 2018·The FEBS Journal·Akshitkumar M MistryJonathan M Irish
Jun 2, 2020·Journal of Medical Virology·Xuefeng Liu, Abdul M Mondal
Aug 10, 2019·World Journal of Stem Cells·Fang-Yu DuGuo-Liang Chen
Apr 4, 2019·PeerJ·Karim RahimiErnst-Martin Füchtbauer
Mar 21, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen B KeysarAntonio Jimeno
Mar 7, 2020·Life Sciences·Elahe TahmasebiAlexander Seifalian

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