PMID: 8943042Nov 26, 1996Paper

myb provides an essential function during Drosophila development

Proceedings of the National Academy of Sciences of the United States of America
Alisa L Katzen, J M Bishop

Abstract

Vertebrate c-myb encodes a transcription factor thought to play an important role in the cell cycle. To gain further insight into myb function, we have been studying a related gene in Drosophila. We found that Drosophila myb is abundantly expressed throughout development in all mitotically active tissues, at lower levels in some postmitotic tissues, but not at detectable levels in polyploid larval tissues. We performed genetic screens to isolate recessive lethal mutations in the chromosomal region that includes the myb gene. We obtained two temperature-sensitive alleles of myb, demonstrating that the gene provides an essential function. Examination of the mutant phenotype revealed that Drosophila myb is important for both embryonic and imaginal development and that myb serves a role in the development of many tissues and during oogenesis.

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Citations

May 11, 2004·Nature Cell Biology·Svetlana CvejicXin-Yun Huang
Apr 24, 2007·Nature Cell Biology·J Robert ManakJoseph S Lipsick
Apr 10, 2002·Development, Growth & Differentiation·Takahiro Akiyama
Sep 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Joseph S Lipsick
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Laura AndrejkaJoseph S Lipsick
Apr 29, 1998·Genes & Development·A L KatzenJ M Bishop
Oct 30, 2012·Genes & Development·Choon Kiat SimAnandasankar Ray
Feb 27, 2013·Molecular and Cellular Biology·Heather DeBruhlJoseph S Lipsick
Oct 28, 2008·BMC Developmental Biology·Jean-Pierre EidMarie Dziadek
Feb 23, 2013·Biology Open·Colin J DavidsonJoseph S Lipsick
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·J Robert ManakJoseph S Lipsick
Dec 20, 2011·Gene Expression Patterns : GEP·Pradeep Kumar BhaskarMousumi Mutsuddi
Jul 2, 2003·Mechanisms of Development·Siau-Min FungAlisa L Katzen
Aug 14, 2001·Blood Cells, Molecules & Diseases·J JacksonA L Katzen
Jan 12, 2012·Genetika·L A Shakina, V Iu Strashniuk
Dec 3, 2004·Genes & Development·Joseph S Lipsick

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