MYC-induced nuclear antigen (MINA) and preeclampsia

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Margarita L Martinez-FierroMarycruz Guerrero-Saucedo

Abstract

Inadequate trophoblast invasion and the subsequent inflammatory response have been implicated in preeclampsia (PE) pathogenesis. Because MYC-induced nuclear antigen (MINA) gene expression is involved in cell proliferation and differentiation, inflammatory response modulation, and the unpaired regulation of which is associated with human diseases, we sought to investigate the connection between MINA and PE. The aim of this study was to evaluate the possible relationship between the MINA rs4857304 variant and susceptibility to PE development as well as to estimate placental MINA gene expression and its association with PE. About 242 pregnant women (126 PE cases and 116 controls) were included. MINA genotyping and gene expression were evaluated by quantitative real-time polymerase chain reaction using TaqMan probes. The G/G genotype of the MINA rs4857304 variant was associated with severe PE (p = 0.027, OR = 1.8, 95% CI = 1.8-3.2). Carriers of one G allele of the MINA rs4857304 variant exhibited a 1.7-fold increased risk of severe PE (p = 0.029, 95% CI = 1.1-3.0). MINA was underexpressed in preeclamptic placentas and MINA expression differed between the mild and severe PE groups. Differences in the expression levels of MINA were f...Continue Reading

References

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Jun 30, 2009·Nature Immunology·Mariko OkamotoMark Bix
May 18, 2011·BMC Pregnancy and Childbirth·Idalia Garza-VelozMargarita L Martinez-Fierro
May 26, 2012·American Journal of Reproductive Immunology : AJRI·Roland BoijLeif Matthiesen
Dec 4, 2013·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·M L Martinez-FierroC Castruita-De la Rosa
Oct 6, 2014·Current Opinion in Immunology·Meenu R PillaiMark Bix
Dec 3, 2014·International Journal of Cardiology·Margarita L Martinez-FierroMaria E Castañeda-Lopez

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