PMID: 9548565Apr 21, 1998Paper

Myc-mediated transactivation of HSP70 expression following exposure to magnetic fields

Journal of Cellular Biochemistry
H LinR Goodman

Abstract

We investigated c-myc protein-binding sites on the HSP70 promoter as modulators of the induction of HSP70 gene expression in response to magnetic field stimulation (8microT at 60Hz) and whether the presence of c-myc protein potentiates transactivation of HSP70 expression. A 320 base pair region in the HSP70 promoter (+1 to -320) was analyzed. This region contains two c-myc-protein binding sites with consensus sequences located at -230 and -160 nucleotide positions (relative to the transcription initiation site) and overlapping with the region reported for the regulation of HSP70 gene expression by c-myc protein. This promoter region is upstream of other regulatory sequences, including the heat shock element (HSE), AP-2, and serum response element (SRE). Transfectants containing both c-myc protein-binding sites, HSP-MYC A and HSP-MYC B, and exposed to magnetic fields showed a 3.0-fold increase in expression of CAT activity as compared with sham-exposed control transfectants. Transfectants containing one c-myc binding site, HSP-MYC A, and exposed to magnetic fields showed a 2.3-fold increase in CAT expression. Transfectants in which both HSP-MYC A and HSP-MYC B binding sites were deleted showed no magnetic field sensitivity; valu...Continue Reading

References

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Citations

Nov 19, 2013·PloS One·Simona Delle MonacheRosella Cardigno Colonna
Feb 2, 2006·International Journal of Radiation Biology·Jae-Seon LeeJeong-Sun Seo
Apr 29, 2009·International Journal of Radiation Biology·Maria T SantiniPietro L Indovina
May 17, 2013·Electromagnetic Biology and Medicine·János RikkFerenc Ihász
Jun 9, 2012·Electromagnetic Biology and Medicine·Martin Blank, Reba M Goodman
Jun 16, 2004·Bioelectromagnetics·Lucia PotenzaMarina Dachà
Mar 10, 2009·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Martin Blank, Reba Goodman
Jan 27, 2009·Progress in Histochemistry and Cytochemistry·Richard H W FunkNurdan Ozkucur
May 27, 2006·Experimental Physiology·Daniel LaubitzElzbieta Grzesiuk
May 1, 2008·Journal of Cellular Physiology·Isaac GeorgeReba Goodman
Jul 19, 2006·International Journal of Radiation Biology·Emel Atli, Hacer Unlü
Jan 6, 2006·Radiation Research·Roberta R AlfieriPier Giorgio Petronini
Dec 14, 2011·The Science of the Total Environment·Stephen J Genuis, Christopher T Lipp
Sep 6, 2000·Journal of Cellular Biochemistry·S CarmodyR Goodman
Nov 25, 1998·Journal of Cellular Biochemistry·L HanR Goodman
Jul 13, 2002·Journal of Cellular Physiology·Reba Goodman, Martin Blank
Feb 17, 2001·Journal of Cellular Biochemistry·H LinR Goodman
Apr 20, 2004·Journal of Cellular Physiology·Martin Blank, Reba Goodman
Aug 10, 2000·Journal of Magnetic Resonance Imaging : JMRI·E A RodegerdtsS H Duda
Aug 24, 2011·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Min Eui HongJi Hoon Jeong
Aug 19, 2006·Bioelectromagnetics·John A RobertsonFrank S Prato
May 2, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Rainer GirgertCarsten Gründker
Aug 27, 1999·Journal of Cellular Biochemistry·H LinR Goodman

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