Myc proteins in brain tumor development and maintenance.

Upsala Journal of Medical Sciences
Fredrik J Swartling

Abstract

Myc proteins are often deregulated in human brain tumors, especially in embryonal tumors that affect children. Many observations have shown how alterations of these pleiotropic Myc transcription factors provide initiation, maintenance, or progression of tumors. This review will focus on the role of Myc family members (particularly c-myc and Mycn) in tumors like medulloblastoma and glioma and will further discuss how to target stabilization of these proteins for future brain tumor therapies.

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Citations

Aug 18, 2012·Nature Reviews. Cancer·Peter K Vogt
Oct 30, 2013·Oncogene·S-M HedeF J Swartling
May 23, 2015·The International Journal of Neuroscience·Qing OuyangLiang Yi
Feb 5, 2013·Experimental Neurology·Fredrik J SwartlingAnders I Persson
Oct 22, 2013·Biochemical and Biophysical Research Communications·Pin GuoQing Mao
Nov 25, 2014·Cell and Tissue Research·Fredrik J SwartlingAnders I Persson
Jun 3, 2017·Molecular Carcinogenesis·Anshika BakshiMohammad Athar
May 26, 2017·Journal of Pathology and Translational Medicine·Sung-Hye ParkSeung-Hong Choi
Dec 21, 2012·International Journal of Oncology·Weiyi XuSongshan Jiang
May 12, 2017·Cellular and Molecular Neurobiology·Mojdeh Mahdian Nasser, Parvin Mehdipour
Oct 24, 2020·International Journal of Molecular Sciences·Olga ZaytsevaLeonie M Quinn
Jun 3, 2021·International Journal of Molecular Sciences·Agata StrejczekAnna-Maria Barciszewska

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Methods Mentioned

BETA
gene knock-out
genotyping
acetylation

Software Mentioned

COSMIC

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