Myc target in myeloid cells-1, a novel c-Myc target, recapitulates multiple c-Myc phenotypes.

The Journal of Biological Chemistry
Xiaoying YinEdward V Prochownik

Abstract

Using cDNA microarrays, we recently identified a large number of transcripts that are regulated differentially by the c-Myc oncoprotein in myeloid cells. Here, we characterize one of these, termed MT-MC1 (Myc Target in Myeloid Cells-1). MT-MC1 is a widely expressed nuclear protein whose overexpression, unlike that of c-Myc targets reported previously, recapitulates multiple c-Myc phenotypes. These include promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation. The MT-MC1 promoter is a direct c-Myc target; it contains two consensus E-box elements, both of which bind c-Myc.Max heterodimers. Mutation of either site abrogates DNA binding by c-Myc.Max and renders the promoter c-Myc unresponsive. Finally, MT-MC1 regulates the expression of several other c-Myc target genes. MT-MC1 represents a proximal and direct c-Myc target that recapitulates many of the properties typically associated with Myc oncoprotein overexpression.

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Citations

Oct 1, 2003·Experimental Cell Research·Maria Grazia BottoneA Ivana Scovassi
Dec 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·David N BooneStephen R Hann
Feb 17, 2010·The Journal of Biological Chemistry·Youjun LiEdward V Prochownik
Nov 20, 2008·The Journal of Biological Chemistry·Youjun LiEdward V Prochownik
Dec 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kenneth R RogulskiEdward V Prochownik
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Youjun LiEdward V Prochownik
Dec 30, 2015·Journal of Cellular and Molecular Medicine·Shuai WuLiang Chu
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Aug 9, 2018·The Journal of Biological Chemistry·Huabo WangEdward V Prochownik
Mar 5, 2021·Science Translational Medicine·Ashraf Ul KabirKyunghee Choi

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