Myc target transcriptomes

Current Topics in Microbiology and Immunology
L A Lee, C V Dang

Abstract

The c-Myc oncogenic transcription factor plays a central role in many human cancers through the regulation of gene expression. Although the molecular mechanisms by which c-Myc and its obligate partner, Max, regulate gene expression are becoming better defined, genes or transcriptomes that c-Myc regulate are just emerging from a variety of different experimental approaches. Studies of individual c-Myc target genes and their functional implications are now complemented by large surveys of c-Myc target genes through the use of subtraction cloning, DNA microarray analysis, serial analysis of gene expression (SAGE), chromatin immunoprecipitation, and genome marking methods. To fully appreciate the differences between physiological c-Myc function in normal cells and deregulated c-Myc function in tumors, the challenge now is to determine how the authenticated transcriptomes effect the various phenotypes induced by c-Myc and to define how c-Myc transcriptomes are altered by the Mad family of proteins.

Citations

Sep 13, 2006·The FEBS Journal·Inken Wierstra, Jürgen Alves
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jonathan R HartKim D Janda
Aug 19, 2007·The FEBS Journal·Claire Dugast-DarzacqNicole B Schreiber-Agus
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Youjun LiEdward V Prochownik
Sep 26, 2007·Molecular and Cellular Biology·Jun-Soo YunElva Díaz
Nov 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Teresa PalomeroAdolfo A Ferrando
Sep 8, 2010·Blood Cells, Molecules & Diseases·Sonali M SmithLucy A Godley

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