Myc/Max/Mad in invertebrates: the evolution of the Max network

Current Topics in Microbiology and Immunology
Peter Gallant

Abstract

The Myc proto-oncogenes, their binding partner Max and their antagonists from the Mad family of transcriptional repressors have been extensively analysed in vertebrates. However, members of this network are found in all animals examined so far. Several recent studies have addressed the physiological function of these proteins in invertebrate model organisms, in particular Drosophila melanogaster. This review describes the structure of invertebrate Myc/Max/Mad genes and it discusses their regulation and physiological functions, with special emphasis on their essential role in the control of cellular growth and proliferation.

Citations

Apr 26, 2011·The Tohoku Journal of Experimental Medicine·Heejei YoonHyunki Kim
Oct 29, 2011·Cellular and Molecular Life Sciences : CMLS·Jonathan R Whitfield, Laura Soucek
Jun 11, 2020·International Journal of Molecular Sciences·Francesca DestefanisPaola Bellosta
Feb 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Markus HartlKlaus Bister
Jul 28, 2006·Cold Spring Harbor Symposia on Quantitative Biology·A OrianR N Eisenman
Aug 19, 2006·Seminars in Cancer Biology·Claire de la Cova, Laura A Johnston

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