PMID: 2111929Feb 1, 1990Paper

Mycobacteria and macrophage activation

Research in Microbiology
R van Furth

Abstract

Recent studies that challenged some older concepts have led to the following conclusions: 1) During an infection of mice with M. bovis, BCG macrophages are activated according to certain criteria, but the increase in their bactericidal or bacteriostatic activity is limited to a small number of bacteria species; 2) interferon-gamma can activate macrophages in vitro and in vivo, but these cells do not exhibit increased bactericidal activity; 3) a 65-kDa protein of mycobacteria can activate macrophages in vivo to a limited degree only; and 4) granulocytes stimulated with interferon-gamma kill ingested M. fortuitum more efficiently than normal granulocytes.

References

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Jan 1, 1987·Immunology Today·D B YoungJ R Lamb

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Citations

Oct 21, 2011·Blood·Melanie J StablesDerek W Gilroy
Jan 13, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Bridget FreyneNigel Curtis
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens FleischerFrank Petersen

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