Mycobacteria-induced granuloma necrosis depends on IRF-1.

Journal of Cellular and Molecular Medicine
Sahar AlyStefan Ehlers

Abstract

In a mouse model of mycobacteria-induced immunopathology, wild-type C57BL/6 (WT), IL-18-knockout (KO) and IFN-alphabeta receptor-KO mice developed circumscript, centrally necrotizing granulomatous lesions in response to aerosol infection with M. avium, whereas mice deficient in the IFN-gamma receptor, STAT-1 or IRF-1 did not exhibit granuloma necrosis. Comparative, microarray-based gene expression analysis in the lungs of infected WT and IRF-1-KO mice identified a set of genes whose differential regulation was closely associated with granuloma necrosis, among them cathepsin K, cystatin F and matrix metalloprotease 10. Further microarray-based comparison of gene expression in the lungs of infected WT, IFN-gamma-KO and IRF-1-KO mice revealed four distinct clusters of genes with variable dependence on the presence of IFN-gamma, IRF-1 or both. In particular, IRF-1 appeared to be directly involved in the differentiation of a type I immune response to mycobacterial infection. In summary, IRF-1, rather than being a mere transcription factor downstream of IFN-gamma, may be a master regulator of mycobacteria-induced immunopathology.

References

Feb 10, 1995·Analytical Biochemistry·P Chomczynski, K Mackey
Nov 1, 1996·Infection and Immunity·P J ConverseM L Pitt
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·J D MacMickingC F Nathan
Jan 1, 1997·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·E R RhoadesI M Orme
Mar 13, 2001·Annual Review of Immunology·J L Flynn, J Chan
Aug 14, 2001·Infection and Immunity·M Quiding-JärbrinkG J Bancroft
Oct 24, 2001·The Journal of Pathology·F BühlingC Röcken
Feb 12, 2002·Bioinformatics·Alexander SturnZlatko Trajanoski
Feb 22, 2002·European Journal of Immunology·Giuliana LosanaFrancesco Novelli
Jun 19, 2002·Biochimica Et Biophysica Acta·Junken AokiHiroyuki Arai
Jan 9, 2003·Microbiology and Immunology·Hiroyuki YamadaIsamu Sugawara
Jan 24, 2004·The Tohoku Journal of Experimental Medicine·Isamu SugawaraSatoru Mizuno
Mar 23, 2004·Annual Review of Immunology·Robert J North, Yu-Jin Jung
Apr 16, 2004·The European Respiratory Journal·F BühlingT Welte
May 27, 2004·The American Journal of Pathology·Frank BühlingTobias Welte
Aug 3, 2004·Nature Reviews. Immunology·William C ParksYolanda S López-Boado
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christoph HölscherStefan Ehlers
Sep 2, 2005·The Journal of Infectious Diseases·Keertan DhedaGraham A W Rook
Feb 14, 2006·Tuberculosis·Randall J BasarabaIan M Orme
Sep 27, 2006·The Journal of Pathology·S AlyS Ehlers
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sylvie AlonsoGeorgiana E Purdy

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Citations

Jul 29, 2010·Ocular Immunology and Inflammation·James T RosenbaumDavid J Wilson

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