Mycobacteria produce proteins involved in biofilm formation and growth-affecting processes

Acta Microbiologica Et Immunologica Hungarica
Joana KorabliovienėPavel Korabliov

Abstract

The aim of this study was to determine the effect of mycobacterial proteins on mycobacterial biofilm formation and growth processes. We separated growth-affecting proteins (GEPs) from wild type of Mycobacterium bovis and ATCC strain of Mycobacterium avium subsp. avium. Our results showed that these mycobacteria-secreted GEPs are involved in biofilm formation, growth stimulatory, and inhibitory processes. Our findings suggest that GEP stimulated M. avium subsp. avium growth in vitro. Stimulation process was observed in mycobacteria affected with GEP extracted from M. avium subsp. avium. We found that both GEPs inhibited the growth of the M. bovis. Optical density measurement and visual analysis confirm that GEP plays an important role in biofilm formation process. Most of M. bovis GEP are associated with the type VII secretion and general secretion pathways. Our results contribute to a better understanding of the mechanisms underlying mycobacterial biofilm formation and growth-affecting processes and better characterization of mycobacterial proteins and their functions. It is noteworthy that this finding represents the first demonstration of GEP-mediated growth effects on a solid and liquid medium.

Citations

Mar 2, 2021·Acta Microbiologica Et Immunologica Hungarica·Joana KorabliovieneArunas Valiulis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Related Papers

Journal of Avian Medicine and Surgery
Anne Burgdorf-MoisukDavid Coleman
Praxis der Pneumologie vereinigt mit Der Tuberkulosearzt
G FORSCHBACHK DEDIE
Applied and Environmental Microbiology
Rodrick J ChiodiniStacy Pfaller
European Journal of Respiratory Diseases
J M Grange
© 2022 Meta ULC. All rights reserved