Mycobacteria-reactive gamma delta T cells in HIV-infected individuals: lack of V gamma 9 cell responsiveness is due to deficiency of antigen-specific CD4 T helper type 1 cells

European Journal of Immunology
D WeschK Pechhold

Abstract

Human gamma delta T lymphocytes expressing the variable T cell receptor elements V gamma 9 paired with V delta 2 are activated by antigen derived from Mycobacterium tuberculosis (M. tb.) and presented by antigen-presenting cells (APC). The subsequent proliferation is strictly dependent on the presence of CD4+ TCR alpha beta+ T helper type 1 (Th1) cells producing interleukin-2 (IL-2). In this study, we report that the reactivity of V gamma 9 cells to M. tb. stimulation in vitro was drastically decreased or absent in the majority of the analyzed HIV-1-infected individuals (CDC stages III and IV). We show that the failure of V gamma 9 cells from HIV+ individuals to proliferate following M. tb. stimulation was not due to an intrinsic qualitative or quantitative defect of gamma delta T cells but rather to a deficiency of M. tb.-reactive CD4 Th1 cells. Thus, V gamma 9 responsiveness could be restored if cultures of M. tb.-stimulated T cells from HIV+ donors were reconstituted with one of the following: (i) exogenous IL-2 (ii) purified CD4 T cells from allogeneic donors; or (iii) T cell-depleted APC from allogeneic donors. In the majority of HIV+ patients, the defective Th1 activity of M. tb.-stimulated CD4 T cells could be decreased ...Continue Reading

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Citations

Oct 1, 1996·Research in Immunology·Y PoquetJ J Fournié
Dec 14, 1999·Microbes and Infection·C T MoritaE Märker-Hermann
May 9, 2000·Microbes and Infection·F HalaryM Bonneville
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Jul 31, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Juliane FazioDieter Kabelitz
Feb 13, 2015·Journal of Virology·Marco CardoneLucia Conti
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cristiana GioiaFabrizio Poccia
Aug 19, 2007·Immunologic Research·Susann BeetzDaniela Wesch
May 22, 2003·Microbes and Infection·Zheng W Chen, Norman L Letvin

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