Mycobacterial glycolipid cord factor trehalose 6,6'-dimycolate causes a decrease in serum cortisol during the granulomatous response

Neuroimmunomodulation
J K ActorAmitava Dasgupta

Abstract

Serum cortisol levels were evaluated in mice following intravenous administration of purified mycobacterial glycolipid trehalose 6,6'-dimycolate (TDM). C57BL/6 mice develop lung granulomas in response to TDM, while A/J mice are deficient in this process. Administration of TDM to C57BL/6 mice led to a rapid reduction in serum cortisol, concurrent with initiation of the granulomatous response and cytokine and chemokine mRNA induction. Cortisol levels were lowest on day 5 after TDM administration, but there was significant production of IL-6, TNF-alpha and IL-1beta messages. Granuloma formation and full immune responsiveness to TDM were only apparent upon a sufficient decrease in levels of systemic cortisol. Treatment of the C57BL/6 mice with hydrocortisone abolished inflammatory responses. Histologically nonresponding A/J mice exhibited higher constitutive serum cortisol and demonstrated different kinetics of cortisol reduction upon administration of TDM. A/J mice demonstrated hyperplastic morphology in the suprarenal gland with a high degree of vacuolization in the medullary region and activation of cells in the zona fasciculata and zona reticularis. The A/J mice were dysregulated with respect to cytokine responses thought to be...Continue Reading

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Citations

Jun 24, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tera V GuidryJeffrey K Actor
Nov 27, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yusuke SakaiHiroyuki Nakayama
Mar 13, 2016·The American Journal of Pathology·Elizabeth DonnachieShen-An Hwang
Feb 7, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Shen-An HwangJeffrey K Actor
Jan 16, 2020·BMC Infectious Diseases·Kassahun Dessie GashuBinyam Tilahun

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