Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells

Proceedings of the National Academy of Sciences of the United States of America
Karsten FischerUlrich E Schaible

Abstract

A group of T cells recognizes glycolipids presented by molecules of the CD1 family. The CD1d-restricted natural killer T cells (NKT cells) are primarily considered to be self-reactive. By employing CD1d-binding and T cell assays, the following structural parameters for presentation by CD1d were defined for a number of mycobacterial and mammalian lipids: two acyl chains facilitated binding, and a polar head group was essential for T cell recognition. Of the mycobacterial lipids tested, only a phosphatidylinositol mannoside (PIM) fulfilled the requirements for CD1d binding and NKT cell stimulation. This PIM activated human and murine NKT cells via CD1d, thereby triggering antigen-specific IFN-gamma production and cell-mediated cytotoxicity, and PIM-loaded CD1d tetramers identified a subpopulation of murine and human NKT cells. This phospholipid, therefore, represents a mycobacterial antigen recognized by T cells in the context of CD1d.

References

Oct 1, 1996·The Journal of Experimental Medicine·A BendelacO Lantz
Dec 23, 1998·European Journal of Immunology·C CouedelM Bonneville
Jun 8, 1999·Annual Review of Immunology·S A Porcelli, R L Modlin
Jun 22, 1999·The Journal of Experimental Medicine·S M BeharM B Brenner
Sep 17, 1999·Tissue Antigens·M HanM A Robinson
Oct 19, 1999·The Journal of Experimental Medicine·O V NaidenkoM Kronenberg
Dec 3, 1999·Microbes and Infection·G SzalayS H Kaufmann
Mar 14, 2000·Immunity·J E GumperzS M Behar
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·U E SchaibleS H Kaufmann
Sep 7, 2000·The Journal of Experimental Medicine·J L MatsudaM Kronenberg
Sep 16, 2000·Trends in Microbiology·U E Schaible, S H Kaufmann
Jan 13, 2001·Current Opinion in Immunology·J L Matsuda, M Kronenberg
Jan 13, 2001·Current Opinion in Immunology·C Watts
Feb 7, 2001·Science·T I PrigozyM Kronenberg
Apr 17, 2001·The Journal of Experimental Medicine·S H ParkA Bendelac
Aug 8, 2001·The Journal of Experimental Medicine·B WangC R Wang
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K FischerU E Schaible
Oct 3, 2001·The Journal of Experimental Medicine·A M DoyleS L Reiner
Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H W MittrückerS H Kaufmann
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin MempelGabriel Gachelin
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karsten FischerUlrich E Schaible
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mischo KursarHans-Willi Mittrücker
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniela O ProcópioRicardo T Gazzinelli
Nov 5, 2002·Nature Immunology·Michael S VincentMichael B Brenner
Dec 24, 2002·Current Opinion in Immunology·Sebastian Joyce, Luc Van Kaer
Jul 9, 2003·The Journal of Experimental Medicine·Dianna Y WuPaul B Chapman
Oct 28, 2003·Nature Immunology·Manfred BriglMichael B Brenner

❮ Previous
Next ❯

Citations

Dec 29, 2005·Journal of Clinical Immunology·Yuki Kinjo, Mitchell Kronenberg
Aug 11, 2005·Current HIV/AIDS Reports·Karla A Eger, Derya Unutmaz
Jun 1, 2005·Trends in Immunology·Johan K Sandberg, Hans-Gustaf Ljunggren
May 22, 2003·Tuberculosis·Stefan H E Kaufmann
Jul 8, 2008·Expert Reviews in Molecular Medicine·William C FlorenceSebastian Joyce
Sep 23, 2011·Journal of Medicinal Chemistry·Gary D AingeGavin F Painter
May 18, 2011·The Journal of Organic Chemistry·Gary D AingeGavin F Painter
Jul 23, 2008·Cell Research·Demin Li, Xiao-Ning Xu
Jun 11, 2008·Immunology and Cell Biology·Anneliese O SpeakFrances M Platt
Jul 10, 2009·Mucosal Immunology·P MatangkasombutD T Umetsu
Jul 10, 2009·Mucosal Immunology·S Middendorp, E E S Nieuwenhuis
Oct 10, 2013·Mucosal Immunology·C Paget, F Trottein
Mar 26, 2005·Nature·Yuki KinjoMitchell Kronenberg
Jul 31, 2007·Nature Chemical Biology·Xiangtian LongPaul B Savage
Aug 23, 2006·Nature Immunology·Dale I Godfrey, Stuart P Berzins
Jul 21, 2006·Nature Immunology·D Branch Moody
Aug 22, 2006·Nature Immunology·Yuki KinjoMitchell Kronenberg
Apr 7, 2005·Nature Medicine·Stefan H E Kaufmann, Andrew J McMichael
May 3, 2005·Nature Reviews. Immunology·D Branch MoodyIan A Wilson
Jun 2, 2005·Nature Reviews. Immunology·Gennaro De Libero, Lucia Mori
Sep 3, 2005·Nature Reviews. Immunology·Louis Schofield, Georges E Grau
Nov 27, 2007·Nature Reviews. Immunology·Duarte C Barral, Michael B Brenner
Dec 17, 2008·Nature Reviews. Immunology·Vincenzo CerundoloMariolina Salio
Nov 17, 2012·Nature Reviews. Immunology·Jamie RossjohnDale I Godfrey
Jan 22, 2013·Nature Reviews. Immunology·Patrick J BrennanMichael B Brenner
May 10, 2007·Nature Reviews. Microbiology·Emmanuel TupinMitchell Kronenberg
Mar 9, 2007·Immunology and Cell Biology·Louis Schofield
Aug 29, 2006·Chemical Society Reviews·Paul B SavageAlbert Bendelac
Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Onisha PatelDale I Godfrey
Aug 10, 2005·The Journal of Experimental Medicine·Stephanie K DouganRichard S Blumberg
Aug 10, 2005·The Journal of Experimental Medicine·Kamel BenlaghaAlbert Bendelac
Jul 20, 2005·The Journal of Experimental Medicine·Christian MünzShin-ichiro Fujii
Nov 9, 2005·The Journal of Experimental Medicine·Nadine Y CroweMark J Smyth
Mar 8, 2006·The Journal of Experimental Medicine·Stephan D GadolaE Yvonne Jones
Jun 8, 2011·The Journal of Experimental Medicine·Dale Ian Godfrey, Jamie Rossjohn
Jun 3, 2009·Transboundary and Emerging Diseases·L Guenin-MacéC Demangel
Jan 24, 2006·Infection and Immunity·Mark L Lang, Aharona Glatman-Freedman
Jul 3, 2008·Annual Review of Cell and Developmental Biology·Jonathan D SilkVincenzo Cerundolo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.