Mycobacterial pulmonary infections in patients with idiopathic pulmonary fibrosis

Journal of Korean Medical Science
Sung-Woo ParkDong Soon Kim


Patients with idiopathic pulmonary fibrosis (IPF) have an increased risk for developing tuberculosis (TB). However, no studies have been reported regarding the development of nontuberculous mycobacterium (NTM) lung disease (NTMLD). We reviewed 795 patients with IPF from five university hospitals who were diagnosed by histological or radio-clinical criteria. In the 795 patients with IPF, pulmonary infections with mycobacterium tuberculosis (MTB) and NTM were found in 35 (4.4%) and 16 patients (2.0%), respectively, which was a higher frequency than that found in the general population. TB was more common in patients treated with immunosuppressants than in those who did not receive immunosuppressants (2.6% vs 1.4%, P = 0.12). Among the IPF patients who had mycobacterial infections,immunosuppressant users developed TB or NTMLD within 1 yr after treatment with immunosuppressants,while those occurred later than 2 yr after diagnosis of IPF in the subjects that did not receive immunosuppressants. Among 51 IPF patients who had mycobacterial infections, 9 (18%) died during follow-up. Of these, three died due to progression of pulmonary tuberculosis. TB and NTMLD is relatively common in patients with IPF in Korea and may be fatal in some ...Continue Reading


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Methods Mentioned


Related Concepts

Hospitals, University
Immunosuppressive Agents
Mycobacterium Infections
Atypical Mycobacterial Infection, Disseminated
Retrospective Studies
Tuberculosis, Pulmonary
Incidence Studies
Idiopathic Pulmonary Fibrosis
Therapeutic Immunosuppression
Lung Diseases

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