Mycobacterial siderophore: A review on chemistry and biology of siderophore and its potential as a target for tuberculosis

European Journal of Medicinal Chemistry
Kavitkumar PatelBhushan Dravyakar

Abstract

Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis is known to secrete low molecular mass compounds called siderophores especially under low iron conditions to chelate iron from host environment. Iron is essential for growth and other essential processes to sustain life of the bacterium in the host. Hence targeting siderophore is considered to be an alternative approach to prevent further virulence of bacterium into the host. This review article presents classification of siderophores, their role in transporting iron into the tubercular cell, biosynthesis of mycobactins, viability of siderophore as a therapeutic target and also focuses on overview on various approaches to target siderophore. The approaches encompass mutation effect on genes involved in siderophore recycling, synthetic as well as natural compounds that can inhibit further spread of bacterium by targeting siderophore.

Citations

Nov 16, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Rahul PalZeeshan Fatima
Apr 30, 2019·Indian Journal of Microbiology·Fábio Muniz de OliveiraAndré Kipnis
Aug 23, 2019·European Journal of Medicinal Chemistry·Huimin KongXiaojian Zhang
Jun 3, 2021·Biomolecules·Awdhesh Kumar Mishra, Kwang-Hyun Baek
Jul 1, 2021·Chemical Reviews·Mira HolzheimerAdriaan J Minnaard
Dec 30, 2020·Journal of Medicinal Chemistry·Mousumi ShyamVenkatesan Jayaprakash
Aug 28, 2021·Antibiotics·Mohd Khairul Nizam MazlanAmirah Mohd Gazzali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
Anthony J HarrisonJ Shaun Lott
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Wu LiJianping Xie
Natural Product Reports
Robert C Hider, Xiaole Kong
© 2022 Meta ULC. All rights reserved