Mycobacterial sulfolipid shows a virulence by inhibiting cord factor induced granuloma formation and TNF-alpha release

Microbial Pathogenesis
Yuko OkamotoIkuya Yano

Abstract

Virulence mechanism of infection with Mycobacterium tuberculosis is currently focused to be clarified in the context of cell surface lipid molecule. Comparing two mycobacterial glycolipids, we observed toxicity and prominent granulomatogenic activity of trehalose 6,6'-dimycolate (TDM) injection in mice, evident by delayed body weight gain and histological observations, whereas 2,3,6,6'-tetraacyl trehalose 2'-sulfate (SL) was non-toxic and non-granulomatogenic. Likewise, TDM but not SL caused temporarily, but marked increase of lung indices, indicative of massive granuloma formation. Interestingly, co-administration of TDM and SL prevented these symptoms distinctively and SL inhibited TDM-induced release of tumor necrosis factor alpha (TNF-alpha) in a dose-dependent manner. Histological findings and organ index changes also showed marked inhibition of TDM induced granuloma formation by co-administration of SL. Simultaneous injection of SL together with TDM was highly effective for this protection, as neither injection 1h before nor after TDM injection showed highly inhibitory. In parallel studies on a cellular level, TDM elicited strong TNF-alpha release from alveolar but not from peritoneal macrophages in vitro. This effect was...Continue Reading

References

Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M B GorenJ A Armstrong
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Dec 1, 1989·American Journal of Respiratory Cell and Molecular Biology·S L KunkelD G Remick
Nov 1, 1988·Infection and Immunity·L ZhangB R Andersen
Jan 1, 1983·International Archives of Allergy and Applied Immunology·S Orbach-ArbouysJ F Petit
Mar 5, 1998·The New England Journal of Medicine·S E ValwayI M Onorato
May 16, 1998·Trends in Microbiology·I M Orme
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel R RoachWarwick J Britton
May 1, 1956·Biochimica Et Biophysica Acta·H NOLLE LEDERER
Dec 1, 1959·Proceedings of the National Academy of Sciences of the United States of America·G MiddlebrookW B Schaefer
Jul 31, 1947·The Journal of Experimental Medicine·G MiddlebrookC Pierce

❮ Previous
Next ❯

Citations

Jul 1, 2011·The Journal of Microbiology·Olivera MarjanovicLee W Riley
Jun 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Pawan KumarCarolyn R Bertozzi
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Landry BlancJérôme Nigou
Aug 26, 2006·Chembiochem : a European Journal of Chemical Biology·Michael W Schelle, Carolyn R Bertozzi
Oct 23, 2010·Journal of the American Chemical Society·Yoann RomboutsYann Guérardel
Oct 13, 2011·Journal of Proteome Research·M Carolina MehaffyKaren M Dobos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.