Mycobacterial T cell responses in HIV-infected patients with advanced immunosuppression

The Journal of Infectious Diseases
Abdulrahman S HammondAssan Jaye

Abstract

Antimycobacterial T cell reactivity at different stages of HIV infection was investigated. Subjects were screened with purified protein derivative (PPD), early secreted antigenic target (ESAT)-6, and culture filtrate protein (CFP)-10 antigens for interferon (IFN)-gamma-producing effector T cell responses by direct ex vivo enzyme-linked immunospot (ELISpot) assay. The proportion of responders to PPD tuberculin decreased with a reduction in CD4 T cell count, whereas the proportion of responder to ESAT-6 and CFP-10 did not. The main sources of IFN-gamma secretion were CD4 cells, and the relative responses to ESAT-6 and CFP-10 significantly increased in HIV-infected patients with decreasing CD4 cell count. This may reflect early signs of reactivation, reinfection, or a restricted, inefficient immune response to Mycobacterium tuberculosis.

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Citations

Nov 13, 2008·The Journal of Infectious Diseases·Christof GeldmacherMichael Hoelscher
Apr 13, 2011·Clinical Microbiology Reviews·Candice K Kwan, Joel D Ernst
Mar 14, 2009·Current Opinion in Infectious Diseases·Melissa R NyendakDavid M Lewinsohn
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Aug 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natalie StricklandCatherine Riou
Jan 8, 2020·Journal of Biomedical Science·María Belén VecchioneMaria Florencia Quiroga
Jan 14, 2017·Microbiology Spectrum·Elsa Du Bruyn, Robert John Wilkinson

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