Mycobacterium avium complex infection in mice: lack of exacerbation after LP-BM5 murine leukemia virus infection.

Infection and Immunity
F GrassiJ J Pocidalo

Abstract

The murine leukemia virus LP-BM5 has been used to reproduce the model of murine AIDS in order to evaluate the course of infection with the MO-1 strain of Mycobacterium avium complex (MAC). LP-BM5 was inoculated in C57BL/6 mice by intravenous (i.v.) injection either 8 weeks before an i.v. challenge with 10(3) or 10(6) CFU of MAC (coinfection 1) or 10 days after an i.v. challenge with 10(3) CFU of MAC (coinfection 2). During coinfection 2 experiments, the phenotypic alterations in blood lymphocyte subsets were analyzed. During coinfection 1, LP-BM5 infection tended to decrease the mycobacterial growth, with the difference reaching statistical significance for the lower inoculum (10(3) CFU of MAC) (P<0.001). During coinfection 2, LP-BM5 did not exacerbate MAC infection except in the spleen, at day 90 after LP-BM5 challenge (P<0.001). LP-BM5 infection and the LP-BM5-MAC coinfection increased the numbers of activated CD4+ lymphocytes (CD4+ Ly6AE+) (P<0.001), activated CD8+ lymphocytes (CD8+ Ly6AE+) (P<0.001), and activated B lymphocytes (Ly5+ Ly6AE+) (P<0.001). This activation of T lymphocytes could explain the lack of exacerbation of MAC infection and even the trend to a lower level of MAC infection. Thus, this model of retroviral ...Continue Reading

References

Jan 1, 1992·Infection and Immunity·R D HubbardF M Collins
Jul 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P Jolicoeur
Feb 19, 1971·Nature·R H BassinP J Fischinger
May 1, 1983·The American Review of Respiratory Disease·P R GangadharamP F Pratt
Nov 1, 1994·Clinical and Experimental Immunology·C LacroixF Derouin
Jul 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A Benson, J J Ellner

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Citations

Feb 28, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Francis DerouinPierre-Marie Girard

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