Mycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010-2012.

Emerging Infectious Diseases
Leah LandeJoseph O Falkinham

Abstract

Attention to environmental sources of Mycobacterium avium complex (MAC) infection is a vital component of disease prevention and control. We investigated MAC colonization of household plumbing in suburban Philadelphia, Pennsylvania, USA. We used variable-number tandem-repeat genotyping and whole-genome sequencing with core genome single-nucleotide variant analysis to compare M. avium from household plumbing biofilms with M. avium isolates from patient respiratory specimens. M. avium was recovered from 30 (81.1%) of 37 households, including 19 (90.5%) of 21 M. avium patient households. For 11 (52.4%) of 21 patients with M. avium disease, isolates recovered from their respiratory and household samples were of the same genotype. Within the same community, 18 (85.7%) of 21 M. avium respiratory isolates genotypically matched household plumbing isolates. Six predominant genotypes were recovered across multiple households and respiratory specimens. M. avium colonizing municipal water and household plumbing may be a substantial source of MAC pulmonary infection.

References

Sep 28, 1989·The New England Journal of Medicine·D S PrinceJ E Fish
Feb 1, 1994·The Journal of Infectious Diseases·R Frothingham, K H Wilson
Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·R J WallaceD E Griffith
Apr 1, 2000·Applied and Environmental Microbiology·R H TaylorM W LeChevallier
May 10, 2002·The British Journal of Radiology·C Wittram, G L Weisbrod
Oct 10, 2002·Clinics in Chest Medicine·Joseph O Falkinham
Oct 10, 2002·Clinics in Chest Medicine·Theodore K Marras, Charles L Daley
Feb 4, 2006·Journal of Clinical Microbiology·Christine Y TurenneMarcel A Behr
Feb 6, 2007·American Journal of Respiratory and Critical Care Medicine·David E GriffithUNKNOWN Infectious Disease Society of America
Mar 31, 2010·BMC Microbiology·Frédéric-Antoine DauchyJeanne Maugein
Jun 21, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K FujitaM Mishima
Jul 10, 2012·American Journal of Respiratory and Critical Care Medicine·Jennifer AdjemianD Rebecca Prevots
Nov 20, 2012·The Lancet Infectious Diseases·Timothy M WalkerTim E A Peto
Apr 15, 2016·Journal of Clinical Microbiology·Robyn S Lee, Marcel A Behr
Oct 26, 2016·PLoS Neglected Tropical Diseases·Jennifer R HondaMichael Strong
Dec 9, 2016·Journal of Clinical Microbiology·David C AlexanderRichard J Wallace
Dec 23, 2016·Annals of the New York Academy of Sciences·Jennifer L Guthrie, Jennifer L Gardy
Oct 14, 2017·Microbial Genomics·Aaron PetkauGary Van Domselaar

❮ Previous
Next ❯

Citations

Oct 24, 2019·Annals of the American Thoracic Society·Connie L TzouGerard A Cangelosi
Jun 4, 2020·International Journal of Environmental Research and Public Health·Ettie M LipnerJames L Crooks
Aug 23, 2020·Pathogens·Simonne GuenetteJoseph O Falkinham
Nov 3, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicholas A TurnerJason E Stout
Aug 24, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Arthur W BakerSarah S Lewis
Aug 20, 2019·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Desak Nyoman Surya Suameitria DewiSohkichi Matsumoto
Aug 26, 2021·Current Opinion in Pulmonary Medicine·Jerry A NickRebecca M Davidson

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR
restriction

Software Mentioned

SNVPhyl
SNPhyl

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.